ITM2A - integral membrane protein 2A Gene

Also Known as E25A; BRICD2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9452

About ITM2A

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:79,360,384-79,367,334 (from NCBI)

This gene has 6 transcripts (splice variants), 174 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 64.9), thyroid (RPKM 48.1) and 23 other tissues.

Summary

This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

ITM2A Products (2)

mRNA Protein Name
NM_001171581.2 NP_001165052.1 integral membrane protein 2A isoform 2
NM_004867.5 NP_004858.1 integral membrane protein 2A isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
15983050 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITM2A Protein Structure

BRICHOS

BRICHOS: BRICHOS domain (133 - 227)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

integral membrane protein 2A

  • BRICHOS domain containing 2A

ITM2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ITM2A O43736 TMED9 Homo sapiens Q9BVK6
Y2H Array
32296183
Intra
ITM2A O43736 TMED9 Homo sapiens Q9BVK6
Y2H Prey Pooling
32296183
Intra
ITM2A O43736 TMED9 Homo sapiens Q9BVK6
Validated Y2H
32296183
Intra
ITM2A O43736 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra
ITM2A O43736 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra
ITM2A O43736 TMEM179B Homo sapiens Q7Z7N9
Validated Y2H
32296183
Intra
ITM2A O43736 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
ITM2A O43736 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
ITM2A O43736 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
ITM2A O43736 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
Intra
ITM2A O43736 FCGR1A Homo sapiens P12314
Y2H Array
32296183
Intra
ITM2A O43736 FCGR1A Homo sapiens P12314
Validated Y2H
32296183
Intra
ITM2A O43736 APP Homo sapiens P05067-4
Anti Bait CoIP
15983050
Intra
ITM2A O43736 APP Homo sapiens P05067-4
Anti Tag CoIP
15983050
Intra
ITM2A O43736 SIT1 Homo sapiens Q9Y3P8
Y2H Prey Pooling
32296183
Intra
ITM2A O43736 SIT1 Homo sapiens Q9Y3P8
Validated Y2H
32296183
Intra
ITM2A O43736 SIT1 Homo sapiens Q9Y3P8
Y2H Array
32296183
Intra
ITM2A O43736 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
ITM2A O43736 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
ITM2A O43736 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
ITM2A O43736 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
ITM2A O43736 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cleft Palate With Or Without Ankyloglossia, X-Linked

  • Cleft Palate With Ankyloglossia

  • CPX

  • X-Linked Cleft Palate And Ankyloglossia

  • X-Linked Cleft Palate With Or Without Ankyloglossia

  • X-Linked Cleft Palate

  • X-Linked Cleft Palate With Ankyloglossia

  • Cleft Palate, With/Without Ankyloglossia, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06983 ITM2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22579 Itm2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29097 Itm2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ITM2A VGNC VGNC:67865
Macaca mulatta ITM2A VGNC VGNC:73798
Bos taurus ITM2A VGNC VGNC:30339
Mus musculus ITM2A MGD MGI:107706
Rattus norvegicus ITM2A RGD RGD:1559423
Others ITM2A NCBI