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Art. -Nr.: HY-153510

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PHD-1-IN-2

PHD-1-IN-2 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1) with an IC₅₀ of 0.07 μM. PHD-1-IN-2 acts as a substrate of MDR1 in MDR1-MDCK cell monolayer assays. PHD-1-IN-2 can be used in the research of ischemia, inflammatory responses and neurodegenerative diseases, such as inflammatory bowel disease and ischemia-reperfusion injury.

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CAS. Nr.: 2009344-53-8
Formel: C₁₆H₁₃N₅O
Molecular Weight:291.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PHD-1-IN-2 Chemical Structure

CAS. Nr.: 2009344-53-8

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Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

In Vitro

PHD-1-IN-2 (Compound 54) is a substrate of MDR1-mediated efflux in MDR1-MDCK cell monolayers, with an efflux rate of 99^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	AUC_0-t	C_max	Bioavailability
Mice^[1]	3 mg/kg	p.o.	/	3658 ng·h/mL	5 μM	100 %
Mice^[1]	0.5 mg/kg	i.v.	17.5 mL/min/kg	/	/	/

Chemical Information

CAS. Nr. 2009344-53-8
Molecular Weight 291.31
Formel C₁₆H₁₃N₅O
SMILES

N#CC=1C=CC(C2=CC(=CC3=NC=NN32)NC(=O)C)=C(C1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
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PHD-1-IN-2

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PHD-1-IN-2 Related Classifications

HY-153510 Related Classifications