2009344-53-8
Chemical Structure
PHD-1-IN-2
- CAS. Nr.: 2009344-53-8
- Formula:C16H13N5O
- Molecular Weight:291.31
IUPAC Name: N-(5-(4-cyano-2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide
InChIKey: SOADHZFGKVPPAW-UHFFFAOYSA-N
SMILES: N#CC=1C=CC(C2=CC(=CC3=NC=NN32)NC(=O)C)=C(C1)C
Biological Activity: PHD-1-IN-2 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1) with an IC50 of 0.07 μM. PHD-1-IN-2 acts as a substrate of MDR1 in MDR1-MDCK cell monolayer assays. PHD-1-IN-2 can be used in the research of ischemia, inflammatory responses and neurodegenerative diseases, such as inflammatory bowel disease and ischemia-reperfusion injury[1].
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PHD-1-IN-2 | PHD-1-IN-2 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1) with an IC50 of 0.07 μM. PHD-1-IN-2 acts as a substrate of MDR1 in MDR1-MDCK cell monolayer assays. PHD-1-IN-2 can be used in the research of ischemia, inflammatory responses and neurodegenerative diseases, such as inflammatory bowel disease and ischemia-reperfusion injury. | |||||||||||||||||||||
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Keywords
