2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. PHD-1-IN-2

PHD-1-IN-2 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1) with an IC50 of 0.07 μM. PHD-1-IN-2 acts as a substrate of MDR1 in MDR1-MDCK cell monolayer assays. PHD-1-IN-2 can be used in the research of ischemia, inflammatory responses and neurodegenerative diseases, such as inflammatory bowel disease and ischemia-reperfusion injury.

For research use only. We do not sell to patients.

PHD-1-IN-2

PHD-1-IN-2 Chemical Structure

CAS No. : 2009344-53-8

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PHD-1-IN-2 Related Antibodies

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Description

PHD-1-IN-2 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1) with an IC50 of 0.07 μM. PHD-1-IN-2 acts as a substrate of MDR1 in MDR1-MDCK cell monolayer assays. PHD-1-IN-2 can be used in the research of ischemia, inflammatory responses and neurodegenerative diseases, such as inflammatory bowel disease and ischemia-reperfusion injury[1].

In Vitro

PHD-1-IN-2 (Compound 54) is a substrate of MDR1-mediated efflux in MDR1-MDCK cell monolayers, with an efflux rate of 99[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PHD-1-IN-2 Related Antibodies
Parmacokinetics
Species Dose Route CL AUC0-t Cmax Bioavailability
Mice[1] 3 mg/kg p.o. / 3658 ng·h/mL 5 μM 100 %
Mice[1] 0.5 mg/kg i.v. 17.5 mL/min/kg / / /
Molecular Weight

291.31

Formula

C16H13N5O
CAS No.
SMILES

N#CC=1C=CC(C2=CC(=CC3=NC=NN32)NC(=O)C)=C(C1)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PHD-1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHD-1-IN-22009344-53-8HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHPHD-1 Inhibitorischemiainflammatory responsesneurodegenerative diseasesInhibitorinhibitorinhibit

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