Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012

  • J Antibiot (Tokyo). 2001 Aug;54(8):635-41. doi: 10.7164/antibiotics.54.635.
H Zhang  1 ,  H Tomoda ,  N Tabata ,  H Miura ,  M Namikoshi ,  Y Yamaguchi ,  R Masuma ,  S Omura
Affiliations
  • 1. The Kitasato Institute, Tokyo, Japan.
PMID: 11592500 DOI: 10.7164/antibiotics.54.635
Abstract

A new Antibiotic termed cladospolide D was isolated along with the known cladospolides A and B from the fermentation broth of Cladosporium sp. FT-0012 by solvent extraction, ODS column chromatography and preparative HPLC. The structure of cladospolide D was deduced to be (E)-2-dodecen-5-hydroxy-11-olide-4-one. Cladospolide D showed Antifungal activity against Pyricularia oryzae and Mucor racemosus.

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