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Art. -Nr.: HY-185488

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seco-CBI dimer

seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.

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CAS. Nr.: 2592397-70-9
Formel: C₄₁H₃₆Cl₂N₄O₅
Molecular Weight:735.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

seco-CBI dimer Chemical Structure

CAS. Nr.: 2592397-70-9

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Biologische Aktivität
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Biologische Aktivität

Beschreibung

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

In Vitro

seco-CBI dimer-based ADCs potently inhibit the growth of CD22-positive lymphoma cells in vitro, with IC₅₀ values ranging from 10 to 80 pM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2592397-70-9
Molecular Weight 735.65
Formel C₄₁H₃₆Cl₂N₄O₅
SMILES

ClC[C@@H]1CN(C2=C1C3=C(C(O)=C2)C=CC=C3)C(/C=C/C4=C(C=C(C=C4)/C=C/C(N5C6=C([C@@H](C5)CCl)C7=C(C(O)=C6)C=CC=C7)=O)NC(CCN)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yao HP, et al. Duocarmycin-based antibody-drug conjugates as an emerging biotherapeutic entity for targeted cancer therapy: Pharmaceutical strategy and clinical progress. Drug Discov Today. 2021;26(8):1857-1874. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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seco-CBI dimer

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

seco-CBI dimer Related Classifications

HY-185488 Related Classifications