Cimoxatone
Based on 1 Customer Validation
Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A).
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 73815-11-9
- Formula: C19H18N2O4
- Molecular Weight:338.36
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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MAO-A |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:250-300 g, Adult male Wistar rats[1]
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Dosage:20 mg/kg
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Administration:P.o.
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Result:Significiantly reduced sucrose intake induced by 1 mg/kg 5-HT or its vehicle injected 2 and 24 h later, significantly enhanced the anorectic action of 5-HT at 2 h but not at 24 h.
Chemical Information
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CAS No. 73815-11-9
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Appearance Solid
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Molecular Weight 338.36
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Formula C19H18N2O4
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SMILES
N#CC1=CC=CC(COC2=CC=C(N3C(OC(COC)C3)=O)C=C2)=C1
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Synonyms
MD 780515
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (295.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9554 mL | 14.7772 mL | 29.5543 mL | 73.8858 mL |
| 5 mM | 0.5911 mL | 2.9554 mL | 5.9109 mL | 14.7772 mL | |
| 10 mM | 0.2955 mL | 1.4777 mL | 2.9554 mL | 7.3886 mL | |
| 15 mM | 0.1970 mL | 0.9851 mL | 1.9703 mL | 4.9257 mL | |
| 20 mM | 0.1478 mL | 0.7389 mL | 1.4777 mL | 3.6943 mL | |
| 25 mM | 0.1182 mL | 0.5911 mL | 1.1822 mL | 2.9554 mL | |
| 30 mM | 0.0985 mL | 0.4926 mL | 0.9851 mL | 2.4629 mL | |
| 40 mM | 0.0739 mL | 0.3694 mL | 0.7389 mL | 1.8471 mL | |
| 50 mM | 0.0591 mL | 0.2955 mL | 0.5911 mL | 1.4777 mL | |
| 60 mM | 0.0493 mL | 0.2463 mL | 0.4926 mL | 1.2314 mL | |
| 80 mM | 0.0369 mL | 0.1847 mL | 0.3694 mL | 0.9236 mL | |
| 100 mM | 0.0296 mL | 0.1478 mL | 0.2955 mL | 0.7389 mL |