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SNRPB2 - small nuclear ribonucleoprotein polypeptide B2 Gene

Also Known as Msl1; U2B''

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6629

About SNRPB2

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:16,730,026-16,742,564 (from NCBI)

This gene has 3 transcripts (splice variants), 248 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 22.1), appendix (RPKM 20.1) and 25 other tissues.

Summary

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SNRPB2 Products (2)

mRNA	Protein	Name
NM_003092.5	NP_003083.1	U2 small nuclear ribonucleoprotein B''
NM_198220.3	NP_937863.1	U2 small nuclear ribonucleoprotein B''

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9716128	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U2 snRNP	IDA IDA: Inferred from direct assay	2951739	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPB2 Protein Structure

RRM_5

RRM_1

0
100
200
225 a.a.

Protein Preferred Names	Protein Names
U2 small nuclear ribonucleoprotein B''	U2 snRNP B''

SNRPB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNRPB2	P08579	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Array	25416956
Intra	SNRPB2	P08579	HOMEZ	Homo sapiens	Q8IX15-3	Validated Y2H	25416956
Intra	SNRPB2	P08579	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	SNRPB2	P08579	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183
Intra	SNRPB2	P08579	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	SNRPB2	P08579	CMTM6	Homo sapiens	Q9NX76	Y2H Array	32296183
Intra	SNRPB2	P08579	CMTM6	Homo sapiens	Q9NX76	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPB2	P08579	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SNRPB2	P08579	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SNRPB2	P08579	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	SNRPB2	P08579	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	SNRPB2	P08579	PNMA1	Homo sapiens	Q8ND90	BFG-2H	27107012
Intra	SNRPB2	P08579	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	27107012
Intra	SNRPB2	P08579	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	SNRPB2	P08579	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	33961781
Intra	SNRPB2	P08579	MCM6	Homo sapiens	Q14566	Y2H Array	25416956
Intra	SNRPB2	P08579	ALAS1	Homo sapiens	P13196	Y2H Array	32296183
Intra	SNRPB2	P08579	ALAS1	Homo sapiens	P13196	Validated Y2H	32296183
Intra	SNRPB2	P08579	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	GABPB1	Homo sapiens	Q06547	Y2H Prey Pooling	25416956
Intra	SNRPB2	P08579	GABPB1	Homo sapiens	Q06547	Y2H Array	25416956
Intra	SNRPB2	P08579	NAP1L5	Homo sapiens	Q96NT1	Validated Y2H	32296183
Intra	SNRPB2	P08579	NAP1L5	Homo sapiens	Q96NT1	Y2H Array	32296183
Intra	SNRPB2	P08579	NAP1L5	Homo sapiens	Q96NT1	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	SNRPB2	P08579	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	SNRPB2	P08579	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	TRIM23	Homo sapiens	P36406	Validated Y2H	32296183
Intra	SNRPB2	P08579	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	SNRPB2	P08579	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SNRPB2	P08579	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SNRPB2	P08579	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	SNRPB2	P08579	GABPB2	Homo sapiens	Q8TAK5	Y2H Array	32296183
Intra	SNRPB2	P08579	GABPB2	Homo sapiens	Q8TAK5	Y2H Prey Pooling	32296183
Intra	SNRPB2	P08579	GABPB2	Homo sapiens	Q8TAK5	Validated Y2H	32296183
Intra	SNRPB2	P08579	SNRPA1	Homo sapiens	P09661	Y2H	22365833
Intra	SNRPB2	P08579	SNRPA1	Homo sapiens	P09661	Y2H Array	31515488
Intra	SNRPB2	P08579	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	33961781
Intra	SNRPB2	P08579	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13503	SNRPB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNRPB2	RGD	RGD:1310194
Felis catus	SNRPB2	VGNC	VGNC:65536
Mus musculus	SNRPB2	MGD	MGI:104805
Macaca mulatta	SNRPB2	VGNC	VGNC:108058
Bos taurus	SNRPB2	VGNC	VGNC:35077
Others	SNRPB2	NCBI