GABPB2 - GA binding protein transcription factor subunit beta 2 Gene

Also Known as GABPB-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126626

About GABPB2

This gene has 6 transcripts (splice variants), 160 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 3.2) and 25 other tissues.

Summary

Enables transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GABPB2 Products (9)

mRNA Protein Name
NM_001323906.2 NP_001310835.1 GA-binding protein subunit beta-2 isoform b
NM_001323907.2 NP_001310836.1 GA-binding protein subunit beta-2 isoform c
NM_001323908.2 NP_001310837.1 GA-binding protein subunit beta-2 isoform a
NM_001323909.2 NP_001310838.1 GA-binding protein subunit beta-2 isoform d
NM_001323910.2 NP_001310839.1 GA-binding protein subunit beta-2 isoform h
NM_001323911.2 NP_001310840.1 GA-binding protein subunit beta-2 isoform e
NM_001323912.2 NP_001310841.1 GA-binding protein subunit beta-2 isoform f
NM_001323913.2 NP_001310842.1 GA-binding protein subunit beta-2 isoform g
NM_144618.3 NP_653219.1 GA-binding protein subunit beta-2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
9857059 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9857059 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9857059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABPB2 Protein Structure

Ank_3

Ank_3: Ankyrin repeat (38 - 62)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (67 - 132)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
Protein Preferred Names Protein Names

GA-binding protein subunit beta-2

  • GA binding protein transcription factor beta subunit 2

GABPB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GABPB2 Q8TAK5 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
GABPB2 Q8TAK5 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
GABPB2 Q8TAK5 LONRF1 Homo sapiens Q17RB8
Y2H Array
32296183
Intra
GABPB2 Q8TAK5 LONRF1 Homo sapiens Q17RB8
Y2H Prey Pooling
32296183
Intra
GABPB2 Q8TAK5 GABPA Homo sapiens Q06546
Anti Tag CoIP
33961781
Intra
GABPB2 Q8TAK5 GABPA Homo sapiens Q06546
Y2H Prey Pooling
32296183
Intra
GABPB2 Q8TAK5 GABPA Homo sapiens Q06546
Anti Tag CoIP
28514442
Intra
GABPB2 Q8TAK5 GABPA Homo sapiens Q06546
Y2H Array
32296183
Intra
GABPB2 Q8TAK5 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
GABPB2 Q8TAK5 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
GABPB2 Q8TAK5 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
GABPB2 Q8TAK5 FLNA Homo sapiens P21333-2
Y2H Array
32814053
Intra
GABPB2 Q8TAK5 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
Intra
GABPB2 Q8TAK5 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Paranoid Schizophrenia

  • Chronic Paranoid Schizophrenia

  • Paranoid Type Schizophrenia

  • Paranoid Type Schizophrenia Subchronic State

  • Paraphrenia - Late

  • Paraphrenic Schizophrenia

  • Schizophrenia, Paranoid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05207 GABPB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05208 GABPB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GABPB2 VGNC VGNC:29190
Rattus norvegicus GABPB2 RGD RGD:1565234
Macaca mulatta GABPB2 VGNC VGNC:72798
Felis catus GABPB2 VGNC VGNC:80214
Mus musculus GABPB2 MGD MGI:95612
Canis familiaris GABPB2 VGNC VGNC:41052
Others GABPB2 NCBI