OVA mRNA (N1-Me-Pseudo UTP)
Based on 1 Customer Validation
OVA mRNA (N1-Me-Pseudo UTP) is an mRNA encoding chicken ovalbumin. The substitution with N1-Me-Pseudo UTP (m1Ψ) improves protein expression and reduces innate immune response. OVA mRNA binds to the STING-activating polymer PD18 and is encapsulated in optimized lipid nanoparticles to construct an mRNA vaccine platform (PD18 LNP). This platform not only enhances the lymphatic delivery efficiency and protein expression of mRNA, but also potently adjuvates immune responses via activating the STING pathway.
For research use only. We do not sell to patients.
-
Storage:
-80°C
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
After OVA mRNA is successfully delivered to antigen-presenting cells (such as dendritic cells, DCs) and translated intracellularly to produce OVA protein, the protein is processed into short peptides (such as SIINFEKL) and presented on the cell surface via major histocompatibility complex class I molecules. This process activates antigen-specific CD8+ T cells, thereby triggering a cellular immune response against target cells expressing the antigen.[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Liquid
-
Shipping
Shipping with dry ice.
-
Storage
-80°C
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OVA mRNA (N1-Me-Pseudo UTP) Related Classifications
HY-174485 Related Classifications
Powered by Bioz