BDCRB (Synonyms: 2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole)

Cat. No.: HY-19296: Data Sheet Handling Instructions
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BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC₅₀ of 0.03 μM for viral yield at 72 h postinfection.

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BDCRB Chemical Structure

CAS No. : 142356-43-2

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Biological Activity
Purity & Documentation
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509174]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509174]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509176]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509175]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509175]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509175]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509176]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509176]
BSC-1	IC₅₀	130 3 Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509174]
HFF	CC₅₀	313.6 3 Compound: BDCRB	Cytotoxicity against HFF after 8 days by XTT assay Cytotoxicity against HFF after 8 days by XTT assay	[PMID: 19786605]
HFF	IC₅₀	0.3 3 Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
carcinoma cell line	IC₅₀	>100 3 Compound: 5	Compound was tested for inhibition activity of human oral carcinoma cell line (KB ) cells in quadruplicate assay. Compound was tested for inhibition activity of human oral carcinoma cell line (KB ) cells in quadruplicate assay.	[PMID: 10882375]
HFF	CC₅₀	313.6 3 Compound: BDCRB	Cytotoxicity against HFF after 8 days by XTT assay Cytotoxicity against HFF after 8 days by XTT assay	[PMID: 19786605]
HFF	IC₅₀	0.34 3 Compound: 4b	Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.41 3 Compound: 4b	Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.41 3 Compound: 4b	Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.3 3 Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	31 3 Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: 4b	Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.34 3 Compound: 4b	Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	8 3 Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: 5	Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells	[PMID: 10882375]
HFF	IC₅₀	0.41 3 Compound: 4b	Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509175]
HFF	IC₅₀	0.7 3 Compound: 4b	Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: 4b	Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509174]
HFF	IC₅₀	0.34 3 Compound: 4b	Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: 5	Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells	[PMID: 10882375]
HFF	IC₅₀	0.7 3 Compound: 5	Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells	[PMID: 10882375]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509174]
HFF	IC₅₀	1.7 3 Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.99 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509175]
HFF	IC₅₀	1.7 3 Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.3 3 Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	118 3 Compound: 4b	Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration	[PMID: 10882374]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509176]
HFF	IC₅₀	0.99 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509175]
HFF	IC₅₀	118 3 Compound: 5	Compound was tested for visual cytotoxicity on human foreskin fibroblasts (HFF) cells Compound was tested for visual cytotoxicity on human foreskin fibroblasts (HFF) cells	[PMID: 10882375]
HFF	IC₅₀	1.7 3 Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	118 3 Compound: 1b (BDCRB)	Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination	[PMID: 15509173]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509174]
HFF	IC₅₀	118 3 Compound: 1b (BDCRB)	Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination	[PMID: 15509173]
HFF	IC₅₀	118 3 Compound: 1b (BDCRB)	Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination	[PMID: 15509173]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509174]
HFF	IC₅₀	118 3 Compound: 4b	Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration	[PMID: 10882374]
HFF	IC₅₀	118 3 Compound: 4b	Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration	[PMID: 10882374]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509175]
HFF	IC₅₀	118 3 Compound: 5	Compound was tested for visual cytotoxicity on human foreskin fibroblasts (HFF) cells Compound was tested for visual cytotoxicity on human foreskin fibroblasts (HFF) cells	[PMID: 10882375]
HFF	IC₅₀	12 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509176]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509174]
HFF	IC₅₀	29 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	29 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	12 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	31 3 Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509175]
HFF	CC₅₀	313.6 3 Compound: BDCRB	Cytotoxicity against HFF after 8 days by XTT assay Cytotoxicity against HFF after 8 days by XTT assay	[PMID: 19786605]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509174]
HFF	IC₅₀	118 3 Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509176]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509175]
HFF	IC₅₀	12 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	6.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	0.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	8 3 Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	29 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	31 3 Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	6.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
KB	IC₅₀	> 100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509176]
HFF	IC₅₀	0.99 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	6.7 3 Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
KB	IC₅₀	> 100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509175]
HFF	IC₅₀	8 3 Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
KB	IC₅₀	>100 3 Compound: 4b	Compound was tested for inhibition of KB cell growth in quadruplicate assay Compound was tested for inhibition of KB cell growth in quadruplicate assay	[PMID: 10882374]
KB	IC₅₀	> 100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509174]
KB	IC₅₀	> 100 3 Compound: 1b (BDCRB)	Concentration required to inhibit KB cell line growth was determined by crystal violet staining method Concentration required to inhibit KB cell line growth was determined by crystal violet staining method	[PMID: 15509173]
KB	IC₅₀	>100 3 Compound: 1b (BDCRB)	Concentration required to inhibit KB cell line growth was determined by crystal violet staining method Concentration required to inhibit KB cell line growth was determined by crystal violet staining method	[PMID: 15509173]
KB	IC₅₀	> 100 3 Compound: 1b (BDCRB)	Concentration required to inhibit KB cell line growth was determined by crystal violet staining method Concentration required to inhibit KB cell line growth was determined by crystal violet staining method	[PMID: 15509173]
NIH3T3	CC₅₀	88.1 3 Compound: BDCRB	Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay	[PMID: 19786605]
KB	IC₅₀	> 100 3 Compound: 4b	Compound was tested for inhibition of KB cell growth in quadruplicate assay Compound was tested for inhibition of KB cell growth in quadruplicate assay	[PMID: 10882374]
KB	IC₅₀	>100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509174]
KB	IC₅₀	>100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509175]
KB	IC₅₀	> 100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509174]
KB	IC₅₀	> 100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509175]
KB	IC₅₀	>100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509176]
KB	IC₅₀	> 100 3 Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509176]
NIH3T3	CC₅₀	88.1 3 Compound: BDCRB	Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay	[PMID: 19786605]
NIH3T3	CC₅₀	88.1 3 Compound: BDCRB	Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay	[PMID: 19786605]
carcinoma cell line	IC₅₀	> 100 3 Compound: 5	Compound was tested for inhibition activity of human oral carcinoma cell line (KB ) cells in quadruplicate assay. Compound was tested for inhibition activity of human oral carcinoma cell line (KB ) cells in quadruplicate assay.	[PMID: 10882375]

Molecular Weight

398.04

Formula

C₁₂H₁₁BrCl₂N₂O₄

CAS No.

142356-43-2

SMILES

O[C@H]1[C@H](N2C3=CC(Cl)=C(Cl)C=C3N=C2Br)O[C@H](CO)[C@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Biron KK, et al. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72. [Content Brief]

BDCRB Related Classifications

Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BDCRB142356-43-22-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazoleCMVCytomegalovirusHCMVmaturational cleavageInhibitorinhibitorinhibit

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BDCRB (Synonyms: 2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole)

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