1. Membrane Transporter/Ion Channel
  2. Sodium Channel
    Na+/Ca2+ Exchanger
  3. Benzamil

Benzamil (Synonyms: Benzylamiloride)

Cat. No.: HY-B1546
Handling Instructions

Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.

For research use only. We do not sell to patients.

Benzamil Chemical Structure

Benzamil Chemical Structure

CAS No. : 2898-76-2

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Description

Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].

In Vitro

Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

319.75

Formula

C₁₃H₁₄ClN₇O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Benzamil
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