2. PROTAC
  3. PROTAC Linkers
  4. BG-PEG4-Amine

BG-PEG4-Amine is a PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

BG-PEG4-Amine

BG-PEG4-Amine Chemical Structure

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BG-PEG4-Amine Related Antibodies

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Description

BG-PEG4-Amine is a PROTAC linker that can be used in the synthesis of PROTACs.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E1122 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BG-PEG4-Amine Related Antibodies
Molecular Weight

517.58

Formula

C24H35N7O6
Appearance

Solid

Color

White to off-white

SMILES

NCCOCCOCCOCCOCCC(NCC1=CC=C(C=C1)COC2=C3NC=NC3=NC(N)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (193.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9321 mL 9.6603 mL 19.3207 mL
5 mM 0.3864 mL 1.9321 mL 3.8641 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9321 mL 9.6603 mL 19.3207 mL 48.3017 mL
5 mM 0.3864 mL 1.9321 mL 3.8641 mL 9.6603 mL
10 mM 0.1932 mL 0.9660 mL 1.9321 mL 4.8302 mL
15 mM 0.1288 mL 0.6440 mL 1.2880 mL 3.2201 mL
20 mM 0.0966 mL 0.4830 mL 0.9660 mL 2.4151 mL
25 mM 0.0773 mL 0.3864 mL 0.7728 mL 1.9321 mL
30 mM 0.0644 mL 0.3220 mL 0.6440 mL 1.6101 mL
40 mM 0.0483 mL 0.2415 mL 0.4830 mL 1.2075 mL
50 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9660 mL
60 mM 0.0322 mL 0.1610 mL 0.3220 mL 0.8050 mL
80 mM 0.0242 mL 0.1208 mL 0.2415 mL 0.6038 mL
100 mM 0.0193 mL 0.0966 mL 0.1932 mL 0.4830 mL
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BG-PEG4-Amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BG-PEG4-AminePROTAC LinkersInhibitorinhibitorinhibit

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BG-PEG4-Amine
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HY-W1130396
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