Bupropion impurity 16

Cat. No.: HY-W701222: Data Sheet Handling Instructions
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Bupropion impurity 16 is an impurity of Bupropion.

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Bupropion impurity 16 Chemical Structure

CAS No. : 192374-15-5

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Biological Activity
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Description

Bupropion impurity 16 is an impurity of Bupropion.

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>100 nM Compound: (R,R)-5a	Inhibition of human SERT in HEK293 cells assessed as inhibition of [3H]serotonin uptake Inhibition of human SERT in HEK293 cells assessed as inhibition of [3H]serotonin uptake	[PMID: 21319801]
HEK293	IC₅₀	>100 μM Compound: (2R,3R)-4a	Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells after 90 mins by scintillation counting Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells after 90 mins by scintillation counting	[PMID: 20509659]
HEK293	IC₅₀	1.6 μM Compound: (R,R)-5a	Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux	[PMID: 21319801]
HEK293	IC₅₀	12 μM Compound: (R,R)-5a	Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux	[PMID: 21319801]
HEK293	IC₅₀	1200 nM Compound: (R,R)-5a	Inhibition of human NET in HEK293 cells assessed as inhibition of [3H]norepinephrine uptake Inhibition of human NET in HEK293 cells assessed as inhibition of [3H]norepinephrine uptake	[PMID: 21319801]
HEK293	IC₅₀	1600 nM Compound: (R,R)-5a	Inhibition of human DAT in HEK293 cells assessed as inhibition of [3H]dopamine uptake Inhibition of human DAT in HEK293 cells assessed as inhibition of [3H]dopamine uptake	[PMID: 21319801]
HEK293	IC₅₀	17 μM Compound: (R,R)-5a	Antagonist activity at human alpha4beta2 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux Antagonist activity at human alpha4beta2 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux	[PMID: 21319801]
HEK293	IC₅₀	241 nM Compound: (2R,3R)-4a	Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells after 90 mins by scintillation counting Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells after 90 mins by scintillation counting	[PMID: 20509659]
HEK293	IC₅₀	630 nM Compound: (2R,3R)-4a	Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells after 90 mins by scintillation counting Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells after 90 mins by scintillation counting	[PMID: 20509659]
HEK293	IC₅₀	9.4 μM Compound: (R,R)-5a	Antagonist activity at human alpha1beta1 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux Antagonist activity at human alpha1beta1 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux	[PMID: 21319801]
SH-SY5Y	IC₅₀	11 μM Compound: (2R,3R)-4a	Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting	[PMID: 20509659]
TE-671	IC₅₀	28 μM Compound: (2R,3R)-4a	Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting	[PMID: 20509659]

Molecular Weight

255.74

Formula

C₁₃H₁₈ClNO₂

CAS No.

192374-15-5

SMILES

O[C@]1([C@@H](C)NC(C)(C)CO1)C2=CC(Cl)=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)