S100A2 - S100 calcium binding protein A2 Gene

Also Known as CAN19; S100L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6273

About S100A2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,561,108-153,565,844 (from NCBI)

This gene has 6 transcripts (splice variants), 323 orthologues and 21 paralogues. Biased expression in esophagus (RPKM 199.3), urinary bladder (RPKM 56.6) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast Cancer. [provided by RefSeq, Jul 2008]

S100A2 Products (3)

mRNA	Protein	Name
NM_001366406.1	NP_001353335.1	protein S100-A2 isoform 2
NM_001366407.1	NP_001353336.1	protein S100-A2 isoform 3
NM_005978.4	NP_005969.2	protein S100-A2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20188096	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15313892	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A2 Protein Structure

S_100

0
97 a.a.

Protein Preferred Names	Protein Names
protein S100-A2

S100A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A2	P29034	S100A3	Homo sapiens	P33764	Validated Y2H	32296183
Intra	S100A2	P29034	S100A3	Homo sapiens	P33764	Complementation	32296183
Intra	S100A2	P29034	S100A3	Homo sapiens	P33764	MAPPIT	32296183
Intra	S100A2	P29034	EZR	Homo sapiens	P15311	FPS	31837246
Intra	S100A2	P29034	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	S100A2	P29034	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	S100A2	P29034	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	S100A2	P29034	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A2	P29034	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	S100A2	P29034	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	S100A2	P29034	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	S100A2	P29034	KPNA2	Homo sapiens	P52292	EMSA Supershift	20965181
Intra	S100A2	P29034	KPNA2	Homo sapiens	P52292	Pull Down	20965181
Intra	S100A2	P29034	MYH9	Homo sapiens	P35579	FPS	31837246
Intra	S100A2	P29034	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100A2	P29034	TP53	Homo sapiens	P04637	GMS	20591429
Intra	S100A2	P29034	MDM2	Homo sapiens	Q00987	SPR	20591429
Intra	S100A2	P29034	MDM4	Homo sapiens	O15151	FPS	31837246
Intra	S100A2	P29034	S100B	Homo sapiens	P04271	Validated Y2H	25416956
Intra	S100A2	P29034	S100A1	Homo sapiens	P23297	Y2H Array	25416956
Intra	S100A2	P29034	S100A1	Homo sapiens	P23297	Y2H Prey Pooling	25416956
Intra	S100A2	P29034	S100A2	Homo sapiens	P29034	Validated Y2H	32296183
Intra	S100A2	P29034	S100A2	Homo sapiens	P29034	Y2H Prey Pooling	32296183
Intra	S100A2	P29034	S100A2	Homo sapiens	P29034	Y2H Array	25416956
Intra	S100A2	P29034	S100A2	Homo sapiens	P29034	Y2H Array	32296183
Intra	S100A2	P29034	S100A2	Homo sapiens	P29034	X-Ray Diffraction	22394450
Intra	S100A2	P29034	S100A2	Homo sapiens	P29034	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72481	S100A2 Protein, Human	P29034 (M1-P98)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74585	S100A2 Protein, Human (HEK293, hFc)	NP_005969.2 (M2-P98)	≥ 95%, as determined by reducing SDS-PAGE.

S100A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81572	S100A2 Antibody	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Epidermoid Cysts	Epidermoid Cyst Sebaceous Cyst Epidermal Inclusion Cyst Epidermal Cyst
Pilomatrixoma	Pilomatricoma PTR Epithelioma Calcificans Of Malherbe Benign Pilomatricoma Calcifying Epithelioma Of Malherbe Pilomatricoma, Somatic Benign Pilomatrixoma Malherbe Calcifying Epithelioma
Conjunctival Intraepithelial Neoplasm	Intraepithelial Neoplasia Of Conjunctiva Conjunctival Intraepithelial Neoplasia
Chondroblastoma	Chondroblastoma Of Bone
Epidermal Appendage Tumor	Neoplasm Of Skin With Adnexal Differentiation Neoplasm Of The Skin Appendage Skin Appendage Tumour
Trachea Leiomyoma	Tracheal Neoplasms Leiomyoma Of The Trachea Tracheal Neoplasm Tracheal Leiomyoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Conjunctival Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Conjunctiva Conjunctival Epidermoid Carcinoma Invasive Squamous Cell Carcinoma Of The Conjunctiva Ocular Surface Squamous Neoplasia
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145900	S100A2-p53-IN-1	Inhibitor	/	Unkown
HY-RS12378	S100A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17517	S100a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23974	S100a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	S100A2	MGD	MGI:3510999
Canis familiaris	S100A2	VGNC	VGNC:45828
Bos taurus	S100A2	VGNC	VGNC:34242
Rattus norvegicus	S100A2	RGD	RGD:6500254
Macaca mulatta	S100A2	VGNC	VGNC:76956
Others	S100A2	NCBI