Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

  • Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4. doi: 10.1002/anie.201300841.
Megan K Thorson  1 ,  Tomas Majtan ,  Jan P Kraus ,  Amy M Barrios
Affiliations
  • 1. Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
PMID: 23512751 DOI: 10.1002/anie.201300841
Abstract

Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.

Products