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Cat. No.: HY-10633R

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SB-705498 (Standard)

SB-705498 (Standard) is the analytical standard of SB-705498 (HY-10633). This product is intended for research and analytical applications. SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC₅₀ of 7.1.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 501951-42-4
Formula: C₁₇H₁₆BrF₃N₄O
Molecular Weight:429.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB-705498 (Standard) Chemical Structure

CAS No.: 501951-42-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Application
Chemical Information
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Bioz

Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 501951-42-4
Molecular Weight 429.23
Formula C₁₇H₁₆BrF₃N₄O
SMILES

BrC1=CC=CC=C1NC(N[C@@H]2CCN(C3=NC=C(C(F)(F)F)C=C3)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Martin J. Gunthorpe, et al. Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor. JPET June 2007 vol. 321 no. 3 1183-1192.

[2]. Rami HK, et al. Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3287-91. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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