Cat. No.: HY-N0077

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Ginkgolic acid

(Synonyms: Ginkgolic acid I)

17 Cited Publications

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Based on 17 publication(s) in Google Scholar

Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

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Pureté: 99.91%
CAS No.: 22910-60-7
Formule: C₂₂H₃₄O₃
Masse moléculaire:346.50

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ginkgolic acid Chemical Structure

CAS No.: 22910-60-7

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (17)
Solvant et solubilité
- In Vitro
- In Vivo
Protocole
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

IC₅₀ & Target

IC50: 3.0 μM (SUMOylation)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	31.3 μg/mL Compound: 5, phenolic acid C15:1	Growth inhibition of human A549 cells after 2 days by SRB assay Growth inhibition of human A549 cells after 2 days by SRB assay	[PMID: 9677265]
CCD-18Co	IC₅₀	97.14 μg/mL Compound: 5, phenolic acid C15:1	Growth inhibition of human CCD-18Co cells after 2 days by SRB assay Growth inhibition of human CCD-18Co cells after 2 days by SRB assay	[PMID: 9677265]
HCT-15	IC₅₀	12.7 μg/mL Compound: 5, phenolic acid C15:1	Growth inhibition of human HCT15 cells after 2 days by SRB assay Growth inhibition of human HCT15 cells after 2 days by SRB assay	[PMID: 9677265]
HT1197	IC₅₀	46.26 μg/mL Compound: 5, phenolic acid C15:1	Growth inhibition of human HT1197 cells after 2 days by SRB assay Growth inhibition of human HT1197 cells after 2 days by SRB assay	[PMID: 9677265]
MCF7	IC₅₀	6.44 μg/mL Compound: 5, phenolic acid C15:1	Growth inhibition of human MCF7 cells after 2 days by SRB assay Growth inhibition of human MCF7 cells after 2 days by SRB assay	[PMID: 9677265]
SK-OV-3	IC₅₀	>50 μg/mL Compound: 5, phenolic acid C15:1	Growth inhibition of human SKOV3 cells after 2 days by SRB assay Growth inhibition of human SKOV3 cells after 2 days by SRB assay	[PMID: 9677265]

In Vitro

Ginkgolic acid inhibits the in vitro SUMOylation of RanGAP1-C2 with the IC₅₀ values of 3.0 μM. The level of SUMOylated p53 is markedly reduced by the ginkgolic acid treatment. Importantly, ginkgolic acid does not affect protein ubiquitination in cells. Ginkgolic acid inhibits the binding between E1 and GA-BODIPY in a dose-dependent manner^[1]. Ginkgolic acid (31.2 μg/mL) inhibits HIV protease activity by 60%, compared with the negative control, and the effect is concentration-dependent. Ginkgolic acid treatment (50 and 100 μg/mL) effectively inhibits HIV infection in human PBMC cells. Ginkgolic acid at the concentrations up to 150 μg/mL does not cause any significant cytotoxicity in Jurkat cells^[2]. GA only inhibits the growth of tumorogenic cell lines in a both dose- and time-dependent manner. Tumor cells are treated with GA for 72 h, 70.53±4.54% Hep-2 and 63.5±7.2% Tca8113 cells are retarded at GO/G1 phase, and the percentage of apoptosis is 40.4±1.58 and 38.4±1.7%, respectively. GA-treated activated caspase-3 downregulates the expression of anti-apoptotic Bcl-2 protein and upregulates the expression of pro-apoptotic Bax protein, eventually leading to a decrease in the Bcl-2/Bax ratio in tumor cellsin human PBMC cells. Ginkgolic acid at the concentrations up to 150 μg/mL does not cause any significant cytotoxicity in Jurkat cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 22910-60-7
Appearance Solid
Masse moléculaire 346.50
Formule C₂₂H₃₄O₃
Color White to off-white
SMILES

O=C(O)C1=C(CCCCCCC/C=C\CCCCCC)C=CC=C1O
Synonyms

Ginkgolic acid I
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (17)

All Cell Proliferation/Viability AssayCell Migration/Invasion AssayIn Vivo Efficacy StudyWBIF

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Journal Impact Factor

Nat Commun

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy. [Abstract]

2022 Sep 3;13(1):5204. PMID: 36057605

Ginkgolic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Sep 3;13(1):5204. [Abstract]

Calu-3 cells were treated with Ginkgolic acid (GA) (5 μM) together with 3-MA (10 mM), Chlorpromazine (CPZ) (10 μM), Methyl-β-cyclodextrin (MβCD) (1 mM), or Cytochalasin D (CD) (2 μM), and the proteins were harvested for immunoblot analysi

Ginkgolic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Sep 3;13(1):5204. [Abstract]

HeLa cells transfected with Flag-ACE2 along with ML-792 (10 μM) or Ginkgolic acid (GA) (5 μM) treatment, followed by labeling of ACE2 (green) with specific antibodies.
Mol Ther

Ginkgolic Acid, a SUMO-1 Inhibitor, Inhibits the Progression of Oral Squamous Cell Carcinoma by Alleviating SUMOylation of SMAD4. [Abstract]

2019 Dec 14;16:86-99. PMID: 31970286

Ginkgolic acid purchased from MedChemExpress. Usage Cited in: Mol Ther. 2019 Dec 14;16:86-99. [Abstract]

Tca8113 cells and Cal-27 cells were incubated with increasing concentrations of Ginkgolic acid (GA) (2, 5, 10, 20, 40 μM) for 24 h. Relative or percent cell viability was determined by CCK-8 assay.

Ginkgolic acid purchased from MedChemExpress. Usage Cited in: Mol Ther. 2019 Dec 14;16:86-99. [Abstract]

Ginkgolic acid (GA) (5, 10 μM, 24 h) significantly suppressed the migration of Tca8113 cells and Cal-27 cells as reported by the wound-healing assay.

Ginkgolic acid purchased from MedChemExpress. Usage Cited in: Mol Ther. 2019 Dec 14;16:86-99. [Abstract]

Tumor growth curve is showing the suppression of growth of Tca8113 residual tumor xenograft tumors by Ginkgolic acid (GA) (20 and 50 mg/kg, p.o.).
Cell Rep Med

Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors. [Abstract]

2026 Apr 21;7(4):102695. PMID: 41881024
J Exp Med

Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity. [Abstract]

2026 May 4;223(5):e20250424. PMID: 41891923
J Transl Med

Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells. [Abstract]

2023 Oct 13;21(1):719. PMID: 37833712
iScience

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL. [Abstract]

2025 Jul 7;28(8):113067. PMID: 40792025
J Biol Chem

SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy. [Abstract]

2025 May 29:110314. PMID: 40449592
Microbiol Spectr

The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis. [Abstract]

2022 Feb 23;10(1):e0099121. PMID: 35019708
Toxicol Appl Pharmacol

Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice. [Abstract]

2018 Apr 15:345:1-9. PMID: 29524504

Ginkgolic acid purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2018 Apr 15:345:1-9. [Abstract]

Ginkgolic acid (GA) reduces cardiac fibrosis and inflammation in ventricular tissue of MI mice. SUMO-1 measured with Western blot. GA: 50 mg/kg per day.
Cell Biochem Funct

SENP3 Promotes Hepatocyte Steatosis via De-SUMOylation of SREBP2. [Abstract]

2025 Nov;43(11):e70141. PMID: 41254938
Placenta

Downregulation of PDCD4 by deSUMOylation associates with the progression of gestational trophoblastic disease. [Abstract]

2022 Dec:130:17-24. PMID: 36370491
J Med Food

Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling. [Abstract]

2021 Aug;24(8):806-816. PMID: 34382859
Scienceasia

2020 Dec.
bioRxiv

2025 August 24.
bioRxiv

2025 May 29.
Research Square Preprint

2021 Jan.
Patent

US20200368199A1.

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (288.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8860 mL

14.4300 mL

28.8600 mL

5 mM

0.5772 mL

2.8860 mL

5.7720 mL

10 mM

0.2886 mL

1.4430 mL

2.8860 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.75 mg/mL (7.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.75 mg/mL (7.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocole

Cell Assay^[2]

Jurkat cells (106 cells/mL) are cultured in the RPMI medium with or without different concentrations of ginkgolic acid for 48 hours to test the cytotoxicity of ginkgolic acid. The cytotoxicity of ginkgolic acid is determined using a tetrazolium compound (MTS) and an electron coupling reagent (PMS). MTS is chemically reduced by cells into formazan, which is soluble in the tissue culture medium. The measurement of the absorbance of the formazan can be carried out using 96 well microplates at 492 nm. Since the production of formazan is proportional to the number of living cells, the intensity of the produced color is a good indication of the viability of the cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fukuda I, et al. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem Biol. 2009 Feb 27;16(2):133-40. [Content Brief]

[2]. Lü JM, et al. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit. 2012 Aug;18(8):BR293-298. [Content Brief]

[3]. Zhou C, et al. Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. Chemotherapy. 2010;56(5):393-402. [Content Brief]

[4]. Qiu F, et al. Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice. Toxicol Appl Pharmacol. 2018 Apr 15;345:1-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8860 mL	14.4300 mL	28.8600 mL	72.1501 mL
	5 mM	0.5772 mL	2.8860 mL	5.7720 mL	14.4300 mL
	10 mM	0.2886 mL	1.4430 mL	2.8860 mL	7.2150 mL
	15 mM	0.1924 mL	0.9620 mL	1.9240 mL	4.8100 mL
	20 mM	0.1443 mL	0.7215 mL	1.4430 mL	3.6075 mL
	25 mM	0.1154 mL	0.5772 mL	1.1544 mL	2.8860 mL
	30 mM	0.0962 mL	0.4810 mL	0.9620 mL	2.4050 mL
	40 mM	0.0722 mL	0.3608 mL	0.7215 mL	1.8038 mL
	50 mM	0.0577 mL	0.2886 mL	0.5772 mL	1.4430 mL
	60 mM	0.0481 mL	0.2405 mL	0.4810 mL	1.2025 mL
	80 mM	0.0361 mL	0.1804 mL	0.3608 mL	0.9019 mL
	100 mM	0.0289 mL	0.1443 mL	0.2886 mL	0.7215 mL

Keywords

Ginkgolic acid

17 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Ginkgolic acid

Activité biologique

Chemical Information

Publications (17)

Solvant et solubilité

Protocole

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Ginkgolic acid Related Classifications

HY-N0077 Related Classifications