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Cat. No.: HY-149610

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Antibacterial agent 156

Antibacterial agent 156 (Compound 57) is a selective and potent bactericidal against C. difficile and targets cell-wall synthesis. Antibacterial agent 156 exhibits bactericidal activity with the minimal inhibitory concentration of 0.5 μg/mL and 1 μg/mL against MIMIC50 (101 strains) and MIC90 (101 strains).

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CAS No.: 3032400-44-2
Formule: C₁₆H₁₅N₅O₄
Masse moléculaire:341.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antibacterial agent 156 Chemical Structure

CAS No.: 3032400-44-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	53.4 μg/mL Compound: 57	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by XTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by XTT assay	[PMID: 37732641]
THP-1	IC₅₀	>128 μg/mL Compound: 57	Cytotoxicity against human THP-1 cells assessed as increase in LDH release incubate for 24 hrs by trypan-blue staining based analysis Cytotoxicity against human THP-1 cells assessed as increase in LDH release incubate for 24 hrs by trypan-blue staining based analysis	[PMID: 37732641]

Chemical Information

CAS No. 3032400-44-2
Masse moléculaire 341.32
Formule C₁₆H₁₅N₅O₄
SMILES

O=[N+](C1=CN=C(C2=NC(C3=CC=C(OC4CCCC4)C=C3)=NO2)N1)[O-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Qian Y, et al. A Potent and Narrow-Spectrum Antibacterial against Clostridioides difficile Infection [published online ahead of print, 2023 Sep 21]. J Med Chem. 2023;10.1021/acs.jmedchem.3c01249. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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