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Cat. No.: HY-181866

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Antibacterial agent 328

Antibacterial agent 328 is a enoyl-ACP reductase (InhA) inhibitor and antimycobacterial agent. Antibacterial agent 328 blocks mycolic acid biosynthesis in Mycobacterium tuberculosis. Antibacterial agent 328 acts on both drug-resistant and drug-susceptible Mycobacterium tuberculosis strains. Antibacterial agent 328 exhibits favorable pharmacokinetic properties, drug-likeness, and a safety-related selectivity index. Antibacterial agent 328 can be used for research on tuberculosis.

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CAS No.: 2670430-25-6
Formule: C₁₈H₁₂BrF₃N₄O
Masse moléculaire:437.21

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 328 Chemical Structure

CAS No.: 2670430-25-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

In Vitro

Antibacterial agent 328 (compound 5l) exhibits favorable safety profiles in HepG2 and THP1 cell lines, with selectivity indices of 23.24 and 13.06, respectively^[1].
Antibacterial agent 328 (0.5-1 μg/mL; 15 d) inhibits the growth of isoniazid-resistant, rifampicin-resistant, and multidrug-resistant Mycobacterium tuberculosis strains^[1].
Antibacterial agent 328 exhibits favorable in silico pharmacokinetic properties and druggability, with no violations of the Rule of Five, and its lipophilicity, solubility and molecular size parameters all meet the required criteria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

INH-resistant, rifampicin-resistant, and multidrug-resistant Mycobacterium tuberculosis
Concentration:

0.5 μg/mL,1 μg/mL
Incubation Time:

15 days
Result:

Showed MIC₅₀s of 1, 0.5, and 1 μg/mL respectively.

Chemical Information

CAS No. 2670430-25-6
Masse moléculaire 437.21
Formule C₁₈H₁₂BrF₃N₄O
SMILES

O=C(N/N=C/C1=CC=C(N2N=CC(Br)=C2)C=C1)C3=CC=C(C(F)(F)F)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kumar P, et al. Structure-activity relationship-driven lead optimization of pyrazole hydrazide-hydrazone analogues as potent antimycobacterial agents: in vitro and in silico studies. Bioorg Med Chem Lett. Published online February 26, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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