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Cat. No.: HY-185463

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β-Tryptase-IN-1

β-Tryptase-IN-1 is a selective β-tryptase inhibitor with a K_i of 10 nM. β-Tryptase-IN-1 binds to the inducible S4⁺ pocket unique to β-tryptase. β-Tryptase-IN-1 can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 725228-46-6
Formule: C₂₇H₂₄F₄N₂O₄
Masse moléculaire:516.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Tryptase-IN-1 Chemical Structure

CAS No.: 725228-46-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

β-Tryptase-IN-1 (Compound 2) (0.0046-10 μM; 30 min) potently inhibits human recombinant β-tryptase with a K_i of 10 nM^[1].
β-Tryptase-IN-1 shows exquisite selectivity, with no detectable inhibition (IC₅₀ >100 μM) against factor Xa, thrombin, trypsin, elastase, or chymase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	Bioavailability	CL	T_1/2	V_ss
Rat^[1]	2 mg/kg	i.v.	/	/	/	8.4 L/h/kg	2.2 h	18.5 L/kg
Rat^[1]	10 mg/kg	p.o.	121 ng/mL	3.7 h	77 %	/	/	/

Chemical Information

CAS No. 725228-46-6
Masse moléculaire 516.48
Formule C₂₇H₂₄F₄N₂O₄
SMILES

O=C(C(F)(F)F)O.O=C(N1CCC(CC1)C2=CC(CN)=CC=C2)C3=CC=C(C#CC4=C(F)C=CC=C4)O3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Liang G, et al. Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent. Bioorg Med Chem Lett. 2012;22(2):1049-1054. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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