Cerebellin TFA
Based on 1 Customer Validation
Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin TFA stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin TFA reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin TFA also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin TFA can be used in neurological research.
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- Pureté: 95.43%
- Formule: C69H113N23O23·xC2HF3O2
- Masse moléculaire:1632.78 (free base)
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Cerebellin (1-100 nM; 10-30 min) TFA potently stimulates the production of norepinephrine and cyclic adenosine monophosphate in rat adrenal medullary tissues via an adenylate cyclase/PKA-dependent pathway[1].
Cerebellin (1-100 nM; 90 min) TFA inhibits glucose-stimulated insulin secretion from isolated rat islets[2].
Cerebellin (100 nM-1 μM; 1 hour) TFA inhibits glucose/Exendin-4 (HY-13443)-stimulated insulin secretion in INS-1 cells[2].
Cerebellin (10 nM-1 μM; 5 min) TFA reduces Forskolin (HY-15371)-induced cAMP accumulation in INS-1 cells in a concentration-dependent manner[2].
Cerebellin (100 nM) TFA irreversibly reduces the intracellular free calcium concentration in INS-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cerebellin (0.5-1.5 nmol/100 g body weight; subcutaneous injection; single bolus) TFA acts as an insulin inhibitor in healthy female Wistar rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (female, 8-12 weeks, 180-190 g)[2]
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Dosage:0.5 nmol/100 g body weight; 1.5 nmol/100 g body weight
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Administration:s.c.; single bolus
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Result:Significantly reduced plasma insulin concentration at both 60 and 120 minutes post-injection at 0.5 nmol/100 g body weight.
Significantly reduced plasma insulin concentration at 120 minutes post-injection at 1.5 nmol/100 g body weight.
Caused a moderate significant increase in plasma glucagon at 60 minutes post-injection at 1.5 nmol/100 g body weight.
Caused a moderate significant decrease in blood glucose at 60 minutes post-injection at 1.5 nmol/100 g body weight.
Chemical Information
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Appearance Solid
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Masse moléculaire 1632.78 (free base)
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Formule C69H113N23O23·xC2HF3O2
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Color White to off-white
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Sequence
Ser-Gly-Ser-Ala-Lys-Val-Ala-Phe-Ser-Ala-Ile-Arg-Ser-Thr-Asn-His
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Sequence Shortening
SGSAKVAFSAIRSTNH
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Albertin G, et al. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Neuropeptides. 2000;34(1):7-11. [Content Brief]
[2]. Strowski MZ, et al. Insulinostatic activity of cerebellin--evidence from in vivo and in vitro studies in rats. Regul Pept. 2009;157(1-3):19-24. [Content Brief]
[3]. Slemmon JR, et al. Cerebellin: a quantifiable marker for Purkinje cell maturation. Proc Natl Acad Sci U S A. 1985;82(20):7145-7148. [Content Brief]
[4]. Mugnaini E, et al. The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain. Proc Natl Acad Sci U S A. 1987;84(23):8692-8696. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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