CLX-0921
CLX-0921 is an orally active PPARγ agonist with an IC50 of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes.
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- CAS No.: 249886-47-3
- Formule: C28H25NO7S
- Masse moléculaire:519.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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PPARγ 1.54 μM (IC50) |
CLX-0921 (0.01 M, 0.1 M, 1.0 M, and 10 M) increases glucose uptake in 3T3-L1 adipocytes. CLX-0921 has potent antihyperglycemic activity with low adipogenic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/KsJ-db/db and C57BL/6J-ob/ob mice (7-week-old)[1]
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Dosage:3.1 mg/kg, 6.3 mg/kg, and 12.5 mg/kg
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Administration:Oral gavage; once daily; for 19 days
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Result:Showed dose-dependent antihyperglycemic activity.
Chemical Information
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CAS No. 249886-47-3
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Masse moléculaire 519.57
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Formule C28H25NO7S
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SMILES
O=C(OC)/C(C1=CC=C(OC2=CC=C(CC(SC(N3)=O)C3=O)C=C2)C=C1)=C/C4=CC(OC)=CC(OC)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CLX-0921 Related Classifications
HY-19394 Related Classifications
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