COX-2-IN-33
COX-2-IN-33 (compound 5f) is a COX-2 inhibitor (IC50=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety.
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- CAS No.: 3049405-60-6
- Formule: C20H13ClF3N5O4
- Masse moléculaire:479.80
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 45.5 nM (COX-2)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
5.74 μM
Compound: 5f
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Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess analysis
Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess analysis
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[PMID: 37224762] |
Chemical Information
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CAS No. 3049405-60-6
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Masse moléculaire 479.80
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Formule C20H13ClF3N5O4
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SMILES
O=C(OCC1=[N+]([O-])ON=C1C2=CC=CC=C2)C3=NN(C4=CC=CC(C(F)(F)F)=C4)C(CCl)=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-33 Related Classifications
HY-149355 Related Classifications
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