CSN5-IN-1
CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells.
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- Formule: C17H22N2O2S
- Masse moléculaire:318.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
IC50: 12.56 μM (CSN5; FP assay); 19 μM (CSN5; Fluor assay)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
24.1 μM
Compound: AC-11
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
|
[PMID: 39129245] |
| HepG2 | IC50 |
39.14 μM
Compound: AC-11
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
|
[PMID: 39129245] |
| MDA-MB-231 | IC50 |
22.8 μM
Compound: AC-11
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
|
[PMID: 39129245] |
Chemical Information
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Masse moléculaire 318.43
-
Formule C17H22N2O2S
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SMILES
O=C(C1=C(C(C)CC2=CC=C(C(C)(C)C)C=C2)SC(N)=N1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)