CypD-IN-7
CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research.
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- Formule: C41H44ClFN6O5
- Masse moléculaire:755.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Cyclophilin
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Activité biologique
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Cyclophilin D 2.4 nM (Ki) |
CypD-IN-7 (18f) (39 nM-5 μM) increases mitochondrial calcium retention capacity (CRC) in isolated mouse liver mitochondria[1].
CypD-IN-7 (10 μM) markedly increases mitochondrial calcium retention capacity (CRC), and provides significantly superior protection against MPTP opening versus cyclosporin A (CsA) at 300 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | Cmax | T1/2 | AUClast | AUCinf |
|---|---|---|---|---|---|---|---|
| Mice[1] | 20 mg/kg | i.p. | 2.00 h | 1633 ng/mL | 3.70 h | 8860 ng·h/mL | 8940 ng·h/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type C57BL6/J male and female mice (10-12 weeks old); CER-AP induced by 7 hourly i.p. injections of caerulein (50 μg/kg)1
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Dosage:20 mg/kg; 50 mg/kg
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Administration:i.p.; administered immediately after the 3rd and 6th Caerulein injections and 2 h after the 7th injection (end of the 2nd, 5th, and 8th hour of the experiment).
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Result:50 mg/kg (three doses) significantly reduced CER-elevated serum amylase, pancreatic MPO activity, and overall histology score; trypsin also showed a marked reduction, while 20 mg/kg showed no significant effect.
Chemical Information
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Masse moléculaire 755.28
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Formule C41H44ClFN6O5
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SMILES
FC1=CC=C(C(N2CCCN2C([C@@H](NC(NCC3=CC4=C(N[C@H]5[C@H](O)CO[C@@H]4C5)C=C3)=O)C6=CC=C(C7=CC=C(CN8CCOCC8)C=C7)C=C6)=O)=C1)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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