FGFR4-IN-9
FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC50 of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC.
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- CAS No.: 3033043-66-9
- Formule: C24H22ClF3N4O4
- Masse moléculaire:522.90
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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FGFR4 75.3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
0.9 μM
Compound: 20
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Antiproliferative activity against human Hep3B cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 37976704] |
| Hep 3B2 | IC50 |
4.5 μM
Compound: 20
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Antiproliferative activity against human Hep3B cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37976704] |
| Huh-7 | IC50 |
12.6 μM
Compound: 20
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Antiproliferative activity against human Huh-7 cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37976704] |
| Huh-7 | IC50 |
7.1 μM
Compound: 20
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Antiproliferative activity against human Huh-7 cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37976704] |
Chemical Information
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CAS No. 3033043-66-9
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Masse moléculaire 522.90
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Formule C24H22ClF3N4O4
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SMILES
C=CC(NC1=CC(F)=CC(Cl)=C1NC2=NC(C)=C(C(C)=N2)OCC3=C(C(OC)=CC(OC)=C3F)F)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Chaudhary CL, et al. 6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation. J Enzyme Inhib Med Chem. 2022 Dec;37(1):844-856. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGFR4-IN-9 Related Classifications
HY-144759 Related Classifications
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