Fluoroethylnormemantine hydrochloride
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Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.
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- Pureté: 98.0%
- CAS No.: 1639210-25-5
- Formule: C12H21ClFN
- Masse moléculaire:233.75
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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NMDA Receptor |
Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1]
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Dosage:0.1, 0.3, 1, 3, 10 mg/kg
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Administration:I.p. 30 minutes before the behavioral tests
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Result:Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.
Chemical Information
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CAS No. 1639210-25-5
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Appearance Solid
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Masse moléculaire 233.75
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Formule C12H21ClFN
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Color White to off-white
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SMILES
[H]Cl.FCC[C@](C[C@H](C1)C2)(C[C@@H]1C3)C[C@]23N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : ≥ 100 mg/mL (427.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Couly S, et, al. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. [Content Brief]
[2]. Chen BK, et, al. Fluoroethylnormemantine, a novel derivative of memantine, facilitates extinction learning without sensorimotor deficits. Int J Neuropsychopharmacol. 2021 Feb 25;pyab007. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2781 mL | 21.3904 mL | 42.7807 mL | 106.9519 mL |
| 5 mM | 0.8556 mL | 4.2781 mL | 8.5561 mL | 21.3904 mL | |
| 10 mM | 0.4278 mL | 2.1390 mL | 4.2781 mL | 10.6952 mL | |
| 15 mM | 0.2852 mL | 1.4260 mL | 2.8520 mL | 7.1301 mL | |
| 20 mM | 0.2139 mL | 1.0695 mL | 2.1390 mL | 5.3476 mL | |
| 25 mM | 0.1711 mL | 0.8556 mL | 1.7112 mL | 4.2781 mL | |
| 30 mM | 0.1426 mL | 0.7130 mL | 1.4260 mL | 3.5651 mL | |
| 40 mM | 0.1070 mL | 0.5348 mL | 1.0695 mL | 2.6738 mL | |
| 50 mM | 0.0856 mL | 0.4278 mL | 0.8556 mL | 2.1390 mL | |
| 60 mM | 0.0713 mL | 0.3565 mL | 0.7130 mL | 1.7825 mL | |
| 80 mM | 0.0535 mL | 0.2674 mL | 0.5348 mL | 1.3369 mL | |
| 100 mM | 0.0428 mL | 0.2139 mL | 0.4278 mL | 1.0695 mL |
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