H1-1 - H1.1 linker histone, cluster member Gene

Also Known as H1A; H1.1; H1F1; HIST1; HIST1H1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3024

About H1-1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,017,032-26,017,787 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-1 Products (1)

mRNA	Protein	Name
NM_005325.4	NP_005316.1	histone H1.1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables chromatin DNA binding	IMP IMP: Inferred from mutant phenotype	15911621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19895577	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in chromatin	IDA IDA: Inferred from direct assay	19882353	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	15911621	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-1 Protein Structure

Linker_histone

0
100
200
215 a.a.

Protein Preferred Names	Protein Names
histone H1.1	H1 histone family, member 1

H1-1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	H1-1	Q02539	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	28514442
Intra	H1-1	Q02539	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	33961781
Intra	H1-1	Q02539	TPPP	Homo sapiens	O94811	Anti Tag CoIP	28514442
Intra	H1-1	Q02539	UTP3	Homo sapiens	Q9NQZ2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tonsil Squamous Cell Carcinoma	Tonsillar Squamous Cell Carcinoma Squamous Cell Carcinoma Of Palatine Tonsil
Narcissistic Personality Disorder
Paraphilia Disorder	Paraphilia Paraphilias
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-18340	(R)-CR8		99.52%	Unkown
HY-18340A	(R)-CR8 trihydrochloride		99.37%	Unkown
HY-N9331	Cimicifugoside H-1		99.83%	Unkown
HY-U00267	Thiazinamium chloride	Inducer	97.44%	Unkown
HY-117146	Indoxacarb		97.86%	Unkown
HY-132733S	1H-1-Ethyl-d5 candesartan		/	Unkown
HY-135180S	1H-1-Ethyl Candesartan Cilexetil-d5		/	Unkown
HY-106465	Proterguride		/	Unkown
HY-135180	1H-1-Ethyl Candesartan Cilexetil		/	Unkown
HY-162679	c-Met degrader-1		/	Unkown
HY-RS05945	H1-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06443	HSPB8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W075249	3,3',5,5'-Tetra(1H-imidazol-1-yl)-1,1'-biphenyl		≥98.0%	Unkown
HY-RS18283	Hspb8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	H1-1	VGNC	VGNC:109855
Mus musculus	H1-1	MGD	MGI:1931523
Canis familiaris	H1-1	VGNC	VGNC:83712
Bos taurus	H1-1	VGNC	VGNC:83548
Rattus norvegicus	H1-1	RGD	RGD:1305706
Macaca mulatta	H1-1	VGNC	VGNC:109665
Others	H1-1	NCBI