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Thiazinamium chloride (Synonyms: Multergan chloride)

Cat. No.: HY-U00267 Purity: 97.44%
Handling Instructions

Thiazinamium chloride possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM.

For research use only. We do not sell to patients.

Thiazinamium chloride Chemical Structure

Thiazinamium chloride Chemical Structure

CAS No. : 4320-13-2

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Description

Thiazinamium chloride possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM.

IC50 & Target

IC50: 0.2 µM (TxB2 synthesis)[1]

In Vitro

TxB2 synthesis by resting macrophages is inhibited by thiazinamium chloride and promethazine in a dose-dependent manner. Thiazinamium chloride inhibits TxBz synthesis but had no effect on the ingestion of zymosan particles. In contrast, chlorpromazine inhibits phagocytosis but not TxBz synthesis except at lo-3 M. Under the condition where indomethacin, a nown cyclooxygenase inhibitor, is inhibitory, promethazine but not thiazinamium chloride inhibits TxB2 synthesis from exogenous arachidonic acid. Treatment of macrophages with promethazine and chlorpromazine but not thiazinamium chloride results in a reduction in the oxidative burst during phagocytosis. Furthermore, the ability of thiazinamium chloride to selectively inhibit arachidonic acid metabolism may contribute to its bronchodilator/antiallergic activity[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Cell Assay
[1]

Rats are anesthetized with an intraperitoneal injections of sodium pentobarbital (43mg/kg body wt) and exsanguinated by cardiac puncture; their lungs are isolated and lavaged with a total of 50mL of lavage solution. Lungs that exhibit infection or gross pathological changes are not used. The lavage fluid containing macrophages is centrifuged at 300g for 10 min, and the cell pellet is resuspended in serum free M199. Macrophage monolayers are established by incubating 1.5x106 cells in petri dishes (35x10mm) for 2 hr in an atmosphere of 95% room air and 5% carbon dioxide. After washing with I-IBSS to remove non-adherent cells, the cultures are incubated in serum-free Ml99 with or without zymosan (100μg/mL) in the absence or presence of drugs(including Thiazinamium chloride)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

334.91

Formula

C₁₈H₂₃ClN₂S

CAS No.

4320-13-2

SMILES

C[N+](C)(C)C(C)CN1C2=C(C=CC=C2)SC3=CC=CC=C13.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Thiazinamium chloride
Cat. No.:
HY-U00267
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Thiazinamium chloride

Cat. No.: HY-U00267