4320-13-2
4320-13-2
Chemical Structure
Thiazinamium chloride
- CAS No.: 4320-13-2
- Formula:C18H23ClN2S
- Molecular Weight:334.91
IUPAC Name: N,N,N-trimethyl-1-(10H-phenothiazin-10-yl)propan-2-aminium chloride
InChIKey: NGYRQLDJZVHTFE-UHFFFAOYSA-M
SMILES: C[N+](C)(C)C(C)CN1C2=C(C=CC=C2)SC3=CC=CC=C13.[Cl-]
Biological Activity: Thiazinamium (chloride) possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM. Thiazinamium (chloride) is structurally similar to H-1 antagonists Promethazine (HY-B1296). Thiazinamium (chloride) stimulates the phosphatidylcholine secretion in adult rat type II pneumocytes[1][2].
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Thiazinamium chloride | Thiazinamium (chloride) possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM. Thiazinamium (chloride) is structurally similar to H-1 antagonists Promethazine (HY-B1296). Thiazinamium (chloride) stimulates the phosphatidylcholine secretion in adult rat type II pneumocytes. | |||||||||||||||||||||
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References
- [1]. Chang J, et al. Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages. Biochem Pharmacol. 1983 Sep 15;32(18):2671-7. [Content Brief]
- [2]. Gilfillan, A. M., et al., (1987). Effects of thiazinamium chloride and other antihistamines on phosphatidylcholine secretion in rat type II pneumocyte cultures. Biochemical pharmacology, 36(2), 277–281. [Content Brief]
