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TPPP - tubulin polymerization promoting protein Gene

Also Known as p24; p25; TPPP1; TPPP/p25; p25alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11076

About TPPP

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:659,862-700,727 (from NCBI)

This gene has 1 transcript (splice variant), 192 orthologues and 2 paralogues. Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues.

Summary

Enables several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including microtubule Cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including mitochondrion; mitotic spindle; and perinuclear region of cytoplasm. Colocalizes with microtubule and microtubule bundle. [provided by Alliance of Genome Resources, Apr 2022]

TPPP Products (1)

mRNA	Protein	Name
NM_007030.3	NP_008961.1	tubulin polymerization-promoting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	21316364	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	21316364	GOA
enables microtubule nucleator activity	IDA IDA: Inferred from direct assay	31522887	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15590652	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	22484033	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26289831	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	17105200	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in astral microtubule organization	IDA IDA: Inferred from direct assay	22328514	GOA
involved in microtubule bundle formation	IDA IDA: Inferred from direct assay	17105200	GOA
involved in microtubule nucleation by microtubule organizing center	IDA IDA: Inferred from direct assay	31522887	GOA
involved in microtubule polymerization	IDA IDA: Inferred from direct assay	18028908	GOA
involved in negative regulation of tubulin deacetylation	IDA IDA: Inferred from direct assay	20308065	GOA
involved in positive regulation of protein polymerization	IDA IDA: Inferred from direct assay	15590652	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	23093407	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	31522887	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18028908	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	18028908	GOA
colocalizes with microtubule bundle	IDA IDA: Inferred from direct assay	17105200	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	22328514	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18028908	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15590652	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPPP Protein Structure

p25-alpha

0
100
200
219 a.a.

Protein Preferred Names	Protein Names
tubulin polymerization-promoting protein	25 kDa brain-specific protein

TPPP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPPP	O94811	ZNF114	Homo sapiens	Q8NC26	Validated Y2H	32296183
Intra	TPPP	O94811	H1-1	Homo sapiens	Q02539	Crosslink	30021884
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	ELISA	27671864
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	CD	27671864
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	NMR	27671864
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	BiFC	27671864

Cross: Cross-species interaction Intra: Intraspecies interaction

TPPP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82440	TPPP Antibody (YA2185)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 3	MRD3 Autosomal Dominant Non-Syndromic Intellectual Disability 3 Mental Retardation, Autosomal Dominant 3 Autosomal Dominant Intellectual Developmental Disorder 3
Striatonigral Degeneration
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Olivopontocerebellar Atrophy	Thomas Syndrome Olivopontocerebellar Atrophies Dejerine-Thomas Syndrome Thomas' Syndrome Wadia-Swami Syndrome Opca Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome Spinocerebellar Ataxia Type 2
Schizophrenia 13	SCZD13 Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related Schizophrenia, Susceptibility To, 13
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14944	TPPP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14945	TPPP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19391	Tppp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19487	Tppp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25883	Tppp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25981	Tppp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TPPP	VGNC	VGNC:102351
Bos taurus	TPPP	VGNC	VGNC:36258
Mus musculus	TPPP	MGD	MGI:1920198
Canis familiaris	TPPP	VGNC	VGNC:47749
Rattus norvegicus	TPPP	RGD	RGD:1310121
Others	TPPP	NCBI