IL-4-IN-3
IL-4-IN-3 is a selective, reversible small-molecule IL-4 inhibitor with a Kd of 31.9 nM for IL-4. IL-4-IN-3 inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes and Ramos B lymphocytes. IL-4-IN-3 can be used in research related to allergic inflammation, cancer, autoimmune diseases, asthma and arthritis.
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- CAS No.: 3104023-25-5
- Formule: C18H13N3O2
- Masse moléculaire:303.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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IL-4 31.9 μM (Kd) |
IL-4-IN-3 (10 μM) potently inhibits the IL-4/IL-13 signaling pathway in HEK Blue IL-4/IL-13 reporter cells, with an EC50 of 0.55 μM[1].
IL-4-IN-3 (2 μM) binds soluble IL-4 to induce a ΔTm of 1.75°C, and binds IL-2 weakly to induce a ΔTm of 0.66°C, whereas it does not cause thermostability changes meeting the binding criteria for IL-7, IL-13, and IL-21[1].
IL-4-IN-3 (5-5000 nM) inhibits IL-4-induced STAT-6 phosphorylation in THP-1 monocytes in a dose-dependent manner[1].
IL-4-IN-3 (50 nM-5 μM) inhibits IL-4-induced STAT-6 phosphorylation in Ramos B lymphocytes at concentrations of 50 nM, 500 nM, and 5 μM[1].
IL-4-IN-3 binds directly to purified IL-4 protein, with a Kd value of 31.9 nM determined by SPR detection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3104023-25-5
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Masse moléculaire 303.31
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Formule C18H13N3O2
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SMILES
N#CC1=C(N)N=C(C2=CC=CC=C2)C=C1C3=CC(O)=C(O)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IL-4-IN-3 Related Classifications
HY-187161 Related Classifications
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