LSD1-IN-23
LSD1-IN-23 is a competitive/non-competitive mixed inhibitor of lysine specific demethylase 1 (LSD1). LSD1-IN-23 has LSD1 inhibitory activity with an IC50 value of 0.58 μM. LSD1-IN-23 can be used for the research of neuroblastoma (NB).
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- CAS No.: 3033660-66-8
- Formule: C19H13BrClN5O2S
- Masse moléculaire:490.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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KDM1/LSD1 0.58 μM (IC50) |
LSD1-IN-23 (Compound 48) (0-100 μM) exhibits effective LSD1 inhibitory activity with an IC50 value of 0.58 μM[1].
LSD1-IN-23 (0.005, 0.037, 0.111, 0.333 μM; 72 h) significantly increases global H3K4Me2 in NB cells[1].
LSD1-IN-23 (0.1 μM; 24 h) has synergistic effect combination treatment with Bortezomib in NB cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHP134 and IMR32 cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Enhanced cytotoxicity in MYCN-amplified NB cells combination treatment of bortezomib with compound 48.
Chemical Information
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CAS No. 3033660-66-8
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Masse moléculaire 490.76
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Formule C19H13BrClN5O2S
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SMILES
O=S(NC(C=CC(Br)=C1)=C1C2=NNN=N2)(C3=CC=C(C=C3)C4=CC=C(C=C4)Cl)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-23 Related Classifications
HY-152032 Related Classifications
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