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Cat. No.: HY-129424

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Mezolidon

(Synonyms: KM-1146)

Mezolidon (KM-1146) is an anti-ulcer agent with weak gastric acid secretion inhibitory activity. Mezolidon prevents the formation of gastric mucosal ulcers in stressed rats, increases and maintains their gastric mucosal blood flow, and inhibits the decrease in their transmucosal potential difference. Mezolidon can be used in the research of gastric ulcers.

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CAS No.: 82697-73-2
Formule: C₁₂H₁₅NO₃S
Masse moléculaire:253.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Mezolidon Chemical Structure

CAS No.: 82697-73-2

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Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vivo

Mezolidon (300 mg/kg; i.p.; single dose; 30 minutes before water-immersion stress initiation) significantly prevents gastric ulcer development in water-immersion restraint stress-exposed rats, with efficacy linked to increased and maintained gastric mucosal blood flow and suppressed reductions in gastric mucosal potential difference, while having no effect on gastroduodenal surface pH or blood viscosity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 160-180 g, gastric ulcer induced by 3-hour water-immersion restraint stress in urethane-anesthetized rats)^[1]
Dosage:

300 mg/kg
Administration:

i.p.; single dose; 30 minutes before water-immersion stress initiation
Result:

Reduced the total length of gastric ulcers to 3.67 mm relative to the control group.
Elevated gastric mucosal blood flow to 119.8% of baseline at 20 min post-stress and 119.2% of baseline at 30 min post-stress, and sustained mucosal blood flow at 66.6% of baseline at 180 min post-stress, both superior to the control group.
Inhibited the decline of gastric mucosal potential difference (PD) at 120 and 180 min post-stress, retaining PD at higher levels than the control group.
Exerted no obvious influence on gastroduodenal mucosal surface pH or water-immersion stress-triggered elevation of blood viscosity.

Chemical Information

CAS No. 82697-73-2
Masse moléculaire 253.32
Formule C₁₂H₁₅NO₃S
SMILES

O=C1NC(C2=CC=C(OC)C(OC)=C2)SC1C
Synonyms

KM-1146
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ashida Y, et al. [Anti-ulcer mechanism of mezolidon on water-immersion stress induced gastric ulcers in rats]. Nihon Yakurigaku Zasshi. 1988 Mar;91(3):121-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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