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Cat. No.: HY-123846

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MLS-0437605

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC₅₀ of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs).

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Pureté: 99.27%
CAS No.: 862975-18-6
Formule: C₁₆H₁₁FN₄O₂S
Masse moléculaire:342.35

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MLS-0437605 Chemical Structure

CAS No.: 862975-18-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 862975-18-6
Appearance Solid
Masse moléculaire 342.35
Formule C₁₆H₁₁FN₄O₂S
Color White to off-white
SMILES

COC1=CC=C(C2=NN=C(NC3=NC4=C(F)C=CC=C4S3)O2)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

J Clin Invest

Differential aortic aneurysm formation provoked by chemogenetic oxidative stress. [Abstract]

2025 Mar 18:e188743. PMID: 40100302

Solvant et solubilité

In Vitro:

DMSO : ≥ 20.83 mg/mL (60.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9210 mL

14.6049 mL

29.2099 mL

5 mM

0.5842 mL

2.9210 mL

5.8420 mL

10 mM

0.2921 mL

1.4605 mL

2.9210 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lucia Musumeci, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015 Feb 17;131(7):656-68. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9210 mL	14.6049 mL	29.2099 mL	73.0247 mL
	5 mM	0.5842 mL	2.9210 mL	5.8420 mL	14.6049 mL
	10 mM	0.2921 mL	1.4605 mL	2.9210 mL	7.3025 mL
	15 mM	0.1947 mL	0.9737 mL	1.9473 mL	4.8683 mL
	20 mM	0.1460 mL	0.7302 mL	1.4605 mL	3.6512 mL
	25 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9210 mL
	30 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL
	40 mM	0.0730 mL	0.3651 mL	0.7302 mL	1.8256 mL
	50 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4605 mL
	60 mM	0.0487 mL	0.2434 mL	0.4868 mL	1.2171 mL

Keywords

MLS-0437605

1 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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MLS-0437605

Metabolism/Protease Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Phosphatase Inhibitor Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MLS-0437605

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

MLS-0437605

Metabolism/Protease Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Phosphatase Inhibitor Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MLS-0437605

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

MLS-0437605 Related Classifications

HY-123846 Related Classifications