Anti-babesial compounds from Curcuma zedoaria

  • Planta Med. 2005 May;71(5):482-4. doi: 10.1055/s-2005-871216.
Ken Kasahara  1 ,  Shinkichi Nomura ,  Subeki ,  Hideyuki Matsuura ,  Masahiro Yamasaki ,  Osamu Yamato ,  Yoshimitsu Maede ,  Ken Katakura ,  Mamoru Suzuki ,  Trimurningsih ,  Chairul ,  Teruhiko Yoshihara
Affiliations
  • 1. Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
PMID: 15977324 DOI: 10.1055/s-2005-871216
Abstract

Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 microg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 microg/mL, respectively.

Products