Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors
- Eur J Pharmacol. 1979 May 1;55(3):323-6. doi: 10.1016/0014-2999(79)90202-4.
PMID: 37098
DOI: 10.1016/0014-2999(79)90202-4
Abstract
3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.
Products
-
Cat. No.Product NameDescriptionTargetResearch Area
-
target: Adrenergic Receptor