Soluble CSF1R alleviates microgliopathy in a CSF1R-related leukoencephalopathy (CRL) mouse model

  • J Neuroinflammation. 2025 Dec 5. doi: 10.1186/s12974-025-03648-4.
Yuhang Zhou  1 ,  Banglian Hu  1 ,  Jie Luo  1 ,  Xingyi Wang  1 ,  Xiaohua Huang  2 ,  Yanfang Li  1 ,  Xian Zhang  1 ,  Guojun Bu  3 ,  Hongsheng Zhang  4  5 ,  Yun-Wu Zhang  6 ,  Honghua Zheng  7  8
Affiliations
  • 1. Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
  • 2. Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
  • 3. Division of Life Science and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • 4. Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. [email protected].
  • 5. Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education); Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 400016, China. [email protected].
  • 6. Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. [email protected].
  • 7. Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. [email protected].
  • 8. Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. [email protected].
PMID: 41350870 DOI: 10.1186/s12974-025-03648-4
Keywords
CRL; CSF1R; Microgliopathy; Soluble CSF1R.
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