RXPA 380
RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM.
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- CAS No.: 564479-79-4
- Formule: C33H36N3O7P
- Masse moléculaire:617.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Ki: 3 nM (C-terminal ACE), 10 μM (N-terminal ACE)[1]
IC50: 2.5 nM (C-domain mutants of human recombinant ACE), 10 μM (N-domain mutants of human recombinant ACE)[1]
RXPA 380 shows Ki(app) values of 12 nM and 12 μM for the C- and N-domain of mouse somatic ACE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL6/J mice[1]
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Dosage:0.9, 3, 10, and 30 mg/kg
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Administration:Intravenous infuse for 30 minutes
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Result:Induced a dose-dependent decrease of the Ang II/Ang I ratio. Blocked the cleavage of exogenously administered bradykinin.
Chemical Information
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CAS No. 564479-79-4
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Masse moléculaire 617.63
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Formule C33H36N3O7P
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SMILES
O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC(C3C(P([C@@H](NC(OCC4=CC=CC=C4)=O)CC5=CC=CC=C5)(O)=O)CCC3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RXPA 380 Related Classifications
HY-18205 Related Classifications
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