564479-79-4
564479-79-4
Chemical Structure
RXPA 380
- CAS No.: 564479-79-4
- Formula:C33H36N3O7P
- Molecular Weight:617.63
IUPAC Name: (2S)-2-(2-(((R)-1-(((benzyloxy)carbonyl)amino)-2-phenylethyl)(hydroxy)phosphoryl)cyclopentanecarboxamido)-3-(1H-indol-3-yl)propanoic acid
InChIKey: IMPJIKIXNAGRCR-SFOGZRFBSA-N
SMILES: O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC(C3C(P([C@@H](NC(OCC4=CC=CC=C4)=O)CC5=CC=CC=C5)(O)=O)CCC3)=O
Biological Activity: RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM[1].
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RXPA 380 | RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM. | |||||||||||||||||||||
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References
Keywords
