15 Results for "

Pyroglutamate

" in MedChemExpress (MCE) Product Catalog:
Products (15)

15 Results for "Pyroglutamate" in MCE Product Catalog:

Cat. No.: HY-P99859
CAS No.: 1931944-80-7
Synonyms: LY3002813

Target:  

Amyloid-β

Domaines de recherche:  

Neurological Disease

Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research .
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Cat. No.: HY-P990078
CAS No.: 2571940-41-3
Synonyms: LY3372993

Target:  

Amyloid-β

Domaines de recherche:  

Neurological Disease

Remternetug (LY3372993) is a monoclonal antibody that targets pyroglutamylated amyloid β fibrils (N3pG-Aβ). Remternetug specifically binds to N3pG-Aβ, thereby clearing amyloid plaques in the brain and reducing amyloid burden. Remternetug can be used in research related to Alzheimer's disease .
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Cat. No.: HY-32290
CAS No.: 54571-66-3
Methyl DL-pyroglutamate is a kind of biochemical reagent.
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Cat. No.: HY-32291
CAS No.: 4931-66-2
Synonyms: (S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
Target:  

NO Synthase

Domaines de recherche:  

Infection Inflammation/Immunology

Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate) is a phenolic compound. Methyl L-pyroglutamate can be isolated from Portulaca oleracea L. Methyl L-pyroglutamate slightly inhibits NO production. Methyl L-pyroglutamate can be used in the research of inflammatory diseases .
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Cat. No.: HY-P4885
CAS No.: 161818-04-8
Synonyms: AβpE3-40
Target:  

Amyloid-β

Domaines de recherche:  

Neurological Disease

Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .
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Cat. No.: HY-P3174
CAS No.: 9075-21-2
Target:  

Aminopeptidase

Domaines de recherche:  

Inflammation/Immunology

Pyroglutamate aminopeptidase I is a type of enzyme that cleaves the peptide bond of pyroglutamic acid linked to the N-terminal end of a protein, including some important anti-inflammatory proteins like immunoglobulin .
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
Target:  

Amyloid-β Tau Protein

Domaines de recherche:  

Neurological Disease

(Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research .
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Cat. No.: HY-41631
CAS No.: 144978-12-1
Synonyms: (S)-Ethyl-N-Boc-Pyroglutamate
Domaines de recherche:  

Others

Boc-Pyr-Oet ((S)-Ethyl-N-Boc-pyroglutamate) is a derivative of L-Pyroglutamic acid (HY-76082). Boc-Pyr-Oet can be used for the synthesis of agents or other compounds.
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Cat. No.: HY-P4886
CAS No.: 157884-74-7
Target:  

Amyloid-β

Domaines de recherche:  

Neurological Disease

Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .
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Cat. No.: HY-P11314
CAS No.: 241145-90-4
Target:  

Amyloid-β

Domaines de recherche:  

Cardiovascular Disease Neurological Disease

ABri, 34 amino acids long, is an Amyloid subunit with certain degree of N- and C-terminal heterogeneity and no sequence identity to any known amyloid protein. ABri is devoid of glycine, methionine, proline, aspartic acid, tryptophane, tyrosine and glutamine, featuring pyroglutamate at its N-terminus. ABri can be used for cerebral hemorrhages, ischemic infarction and Alzheimer disease research .
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Cat. No.: HY-W286423
CAS No.: 66642-36-2
L-Pyroglutamic acid 7-amido-4-methylcoumarin is a fluorogenic substrate for pyroglutamate aminopeptidase 1 (PGP-1) .
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Cat. No.: HY-E70930
Target:  

Aminopeptidase

Domaines de recherche:  

Metabolic Disease

Pyroglutamate Aminopeptidase, Thermococcus thioreducens, is an enzyme capable of digesting proteins. Pyroglutamate Aminopeptidase specifically acts on the N-terminal pyroglutamic acid, cleaving it from proteins and peptide chains, thereby promoting Edman degradation.
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Cat. No.: HY-E70930A
Target:  

Aminopeptidase

Domaines de recherche:  

Metabolic Disease

Pyroglutamate Aminopeptidase, Pyrococcus furiosus (EC 3.4.19.3), is an enzyme capable of digesting proteins. Pyroglutamate Aminopeptidase specifically acts on the N-terminal pyroglutamic acid, cleaving it from proteins and peptide chains, thereby promoting Edman degradation.
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Cat. No.: HY-181797
Target:  

Amyloid-β CD47

Domaines de recherche:  

Cancer

CL121 is a Glutaminyl Cyclase inhibitor with an IC50 of 0.07 μM against human sQC and an IC50 of 0.54 μM against human gQC. CL121 reduces the level of pyroglutamate (pE)-modified CD47 on the surface of cancer cells. CL121 exhibits anti-tumor activity against triple-negative breast cancer .
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Cat. No.: HY-P99859A
CAS No.: 1931944-80-7
Synonyms: LY3002813 (powder)

Target:  

Amyloid-β

Domaines de recherche:  

Neurological Disease

Donanemab (LY3002813) (powder) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab (powder) has the potential for early Alzheimer's disease research .
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