183449-57-2
Chemical Structure
(Pyr3)-Amyloid β-Protein (3-42)
- CAS No.: 183449-57-2
- Formula:C196H299N53O55S
- Molecular Weight:4309.86
SMILES: O=C([C@@H](N)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)[C@H](CC)C)=O)C(C)C)=O)C(C)C)=O)=O)=O)C(C)C)=O)CCSC)=O)CC(C)C)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C)=O)=O)CCCCN)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)C(C)C)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)CC4=CNC=N4)=O)CC5=CNC=N5)=O)C(C)C)=O)CCC(O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)CO)=O)CC(O)=O)=O)CC7=CNC=N7)=O)CCCNC(NC([C@@H](N8)CCC8=O)=O)=N
Biological Activity: (Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research[1][2].
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(Pyr3)-Amyloid β-Protein (3-42) | (Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research. | |||||||||||||||||||||
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References
- [1]. He W, et al. The Aβ 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater β-sheet forming and aggregation propensities in vitro than full-length Aβ. Biochemistry. 1999;38(33):10871-10877. [Content Brief]
- [2]. Nussbaum JM, et al. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature. 2012 May 02;485(7400):651-5. [Content Brief]
