183449-57-2
Chemical Structure
(Pyr3)-Amyloid β-Protein (3-42)
- CAS No.: 183449-57-2
- Formula:C196H299N53O55S
- Molecular Weight:4309.86
SMILES: O=C([C@@H](N)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)[C@H](CC)C)=O)C(C)C)=O)C(C)C)=O)=O)=O)C(C)C)=O)CCSC)=O)CC(C)C)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C)=O)=O)CCCCN)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)C(C)C)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)CC4=CNC=N4)=O)CC5=CNC=N5)=O)C(C)C)=O)CCC(O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)CO)=O)CC(O)=O)=O)CC7=CNC=N7)=O)CCCNC(NC([C@@H](N8)CCC8=O)=O)=N
Biological Activity: (Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated and pyroglutamate-modified amyloid β peptide. (Pyr3)-Amyloid β-Protein (3-42) spontaneously aggregates into soluble oligomers and β-sheet-structured fibrils, causing neuronal cytotoxicity and leading to decreased expression of postsynaptic density protein 95 (PSD-95) in mouse cortex, thereby inducing synaptic dysfunction in spatial and short-term memory. (Pyr3)-Amyloid β-Protein (3-42) can be used for research on Alzheimer's disease[1][2].
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(Pyr3)-Amyloid β-Protein (3-42) | (Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated and pyroglutamate-modified amyloid β peptide. (Pyr3)-Amyloid β-Protein (3-42) spontaneously aggregates into soluble oligomers and β-sheet-structured fibrils, causing neuronal cytotoxicity and leading to decreased expression of postsynaptic density protein 95 (PSD-95) in mouse cortex, thereby inducing synaptic dysfunction in spatial and short-term memory. (Pyr3)-Amyloid β-Protein (3-42) can be used for research on Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Jonson M, et al. Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues. PloS one. 2015;10(7):e0133272.
- [2]. Cho I, et al. Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β3-42 peptide. Sci Rep. 2023;13(1):505.
