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Cat. No.: HY-147010

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STING agonist-12

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC₅₀ of 185 nM.

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Pureté: 98.35%
CAS No.: 2259624-71-8
Formule: C₂₅H₁₉ClF₄N₂O₂
Masse moléculaire:490.88

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

STING agonist-12 Chemical Structure

CAS No.: 2259624-71-8

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC₅₀ of 185 nM^[1].

IC₅₀ & Target

EC₅₀: 185 nM (STING)^[1]

In Vitro

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells^[1].
STING agonist-12 is not active at mouse STING^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c mice (n=3)^[1]
Dosage:

5 or 10 mpk
Administration:

Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
Result:

Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse^[1].

Route DOSE
(mpk) AUC
(ng/mL*h) T_1/2
(h) C_max
(ng/mL) V_d
(mL/kg) F
(%)

IV 5 1215 1.41 1867 2689 NA

PO 10 2090 NA 1723 NA 86

Chemical Information

CAS No. 2259624-71-8
Appearance Solid
Masse moléculaire 490.88
Formule C₂₅H₁₉ClF₄N₂O₂
Color Light yellow to yellow
SMILES

ClC1=CC=CC(F)=C1CN2C3=C(C(C)(C2=O)C)C=CC(C(NCC4=C(C=C(C=C4F)F)F)=O)=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Immunity

A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement. [Abstract]

2025 Dec 5:S1074-7613(25)00506-0. PMID: 41352342

STING agonist-12 purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]

THP1-Lucia ISG cells were treated with GNE-6468 (25 μM), STING agonist-12 (C53, 10 μM), and NVS-STG2 (5 μM) in the presence or absence of BFA (1 μM) for 6 h. Activation of the STING pathway was analyzed by immunoblotting.

STING agonist-12 purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]

Western blot analysis of the LC3 conversion in WT HEK293T cells and HEK293T cells stably expressing hSTING stimulated with cGAMP (4 μM), GNE-6468 (25 μM), and STING agonist-12 (C53, 10 μM) for 8 h.
J Med Chem

Design, Synthesis, and Biological Evaluation of Selective STING Synergists That Enhance cGAMP-STING Pathway Activation without Inherent Agonist Activity. [Abstract]

2025 Apr 29. PMID: 40298091

Solvant et solubilité

In Vitro:

DMSO : 250 mg/mL (509.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0372 mL

10.1858 mL

20.3716 mL

5 mM

0.4074 mL

2.0372 mL

4.0743 mL

10 mM

0.2037 mL

1.0186 mL

2.0372 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0372 mL	10.1858 mL	20.3716 mL	50.9289 mL
	5 mM	0.4074 mL	2.0372 mL	4.0743 mL	10.1858 mL
	10 mM	0.2037 mL	1.0186 mL	2.0372 mL	5.0929 mL
	15 mM	0.1358 mL	0.6791 mL	1.3581 mL	3.3953 mL
	20 mM	0.1019 mL	0.5093 mL	1.0186 mL	2.5464 mL
	25 mM	0.0815 mL	0.4074 mL	0.8149 mL	2.0372 mL
	30 mM	0.0679 mL	0.3395 mL	0.6791 mL	1.6976 mL
	40 mM	0.0509 mL	0.2546 mL	0.5093 mL	1.2732 mL
	50 mM	0.0407 mL	0.2037 mL	0.4074 mL	1.0186 mL
	60 mM	0.0340 mL	0.1698 mL	0.3395 mL	0.8488 mL
	80 mM	0.0255 mL	0.1273 mL	0.2546 mL	0.6366 mL
	100 mM	0.0204 mL	0.1019 mL	0.2037 mL	0.5093 mL

Keywords

STING agonist-12

2 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

1/16
1/16

STING agonist-12 purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]

Customer Validation
THP1-Lucia ISG cells were treated with GNE-6468 (25 μM), STING agonist-12 (C53, 10 μM), and NVS-STG2 (5 μM) in the presence or absence of BFA (1 μM) for 6 h. Activation of the STING pathway was analyzed by immunoblotting.
1/16

STING agonist-12 purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]

Customer Validation
Western blot analysis of the LC3 conversion in WT HEK293T cells and HEK293T cells stably expressing hSTING stimulated with cGAMP (4 μM), GNE-6468 (25 μM), and STING agonist-12 (C53, 10 μM) for 8 h.

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STING agonist-12

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Orally Active Compound Library

Immunopotentiator Compound Library

Bioactive Compound Library Max

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Publications Citing Use of MedChemExpress (MCE) STING agonist-12

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Route	DOSE (mpk)	AUC (ng/mL*h)	T_1/2 (h)	C_max (ng/mL)	V_d (mL/kg)	F (%)
IV	5	1215	1.41	1867	2689	NA
PO	10	2090	NA	1723	NA	86

STING agonist-12

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Orally Active Compound Library

Immunopotentiator Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) STING agonist-12

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

STING agonist-12 Related Classifications

HY-147010 Related Classifications