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Cat. No.: HY-173326

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STING-IN-14

STING-IN-14 is an inhibitor of STING (IC₅₀: 0.6 nM). STING-IN-14 inhibits the activation of the IRF pathway in THP1-Dual^TM cells. STING-IN-14 can be used in autoimmune diseases research.

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CAS No.: 3070953-78-2
Formule: C₄₆H₄₃F₂N₁₁O₅
Masse moléculaire:867.90

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

STING-IN-14 Chemical Structure

CAS No.: 3070953-78-2

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

STING-IN-14 is an inhibitor of STING (IC₅₀: 0.6 nM). STING-IN-14 inhibits the activation of the IRF pathway in THP1-Dual^TM cells. STING-IN-14 can be used in autoimmune diseases research^[1].

In Vitro

STING-IN-14 (Example 50) (20-24 h) inhibits the activation of IRF pathway in THP1-Dual^TM cells (IC₅₀: 2 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3070953-78-2
Masse moléculaire 867.90
Formule C₄₆H₄₃F₂N₁₁O₅
SMILES

[H][C@]1(C(NC[C@@H](C(NCC2=CC=CC=C2)=O)NC([C@]3([H])C[C@@](O4)([H])CN3C5=NC=NC6=C5C=NN6C7=C(F)C=C(F)C=C7)=O)=O)N(CCN8N=C(C=CC=C9C%10=CC=CC4=C%10)C9=C8)CCOC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. 1. Han X, et al. Macrocycles for the treatment of autoimmune disease and their preparation. WO2025021666. F. Hoffmann-La Roche AG, Switzerland. 2025-01-30.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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