UT-B-IN-2
UT-B-IN-2 is an orally active UT-B inhibitor, with an IC50 of 0.11 μM in mice and 0.054 μM in rats. UT-B-IN-2 induces diuretic effects in rats. UT-B-IN-2 can be used in the research of cardiovascular diseases and edema-related diseases.
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- Formule: C10H9N3O3
- Masse moléculaire:219.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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mUT-B 0.11 μM (IC50) |
rUT-B 0.054 μM (IC50) |
UT-B-IN-2 (12f) (0.005-40 μM; 5 min) potently inhibits mouse UT-B with an IC50 of 0.11 μM and rat UT-B with an IC50 of 0.054 μM in an erythrocyte lysis assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | Cmax | T1/2 | Bioavailability |
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| Rat[1] | 50 mg/kg | p.o. | 0.5 h | 1690 ng/mL | 0.99 h | 61.9 % |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 170-200 g)[1]
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Dosage:50 mg/kg; 100 mg/kg
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Administration:p.o.; single dose
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Result:Significantly increased urine output compared to vehicle control, with dose-dependent activity observed.
Showed significant diuresis starting at 16 h post-administration, lasting for 24 h, and urine output peaked at 24-32 h post-administration, reaching 3-fold the control levels (50 mg/kg).
Showed significant diuresis starting at 8 h post-administration, lasting for 40 h, and urine output peaked at 24-32 h post-administration, reaching 3.5-fold the control levels (100 mg/kg).
Chemical Information
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Masse moléculaire 219.20
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Formule C10H9N3O3
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SMILES
O=C(C1=CC=C(C(C)=O)O1)NC2=CC=NN2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UT-B-IN-2 Related Classifications
HY-184585 Related Classifications
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