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Cat. No.: HY-129141

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YKL-06-062

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC₅₀ of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively.

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Pureté: 99.44%
CAS No.: 2172617-16-0
Formule: C₃₁H₃₉N₇O
Masse moléculaire:525.69

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

YKL-06-062 Chemical Structure

CAS No.: 2172617-16-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC₅₀ of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively^[1].

Voir tous les produits spécifiques à Isoform Salt-inducible Kinase (SIK) :

In Vitro

YKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

Human melanocyte cells, UACC62 melanoma cells
Concentration:

0.0004 μM, 0.004 μM, 0.04 μM, 0.4 μM, 4 μM,8 μM,16 μM
Incubation Time:

3 hours
Result:

Unregulated MITF mRNA expression.

Chemical Information

CAS No. 2172617-16-0
Appearance Solid
Masse moléculaire 525.69
Formule C₃₁H₃₉N₇O
Color Light yellow to yellow
SMILES

O=C1N(C2CCCCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3CN1C6=C(C)C=CC=C6C
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Br J Pharmacol

Dual pharmacological targeting of coactivator-associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice. [Abstract]

2026 Apr 29. PMID: 42055601
Mediators Inflamm

Inhibition of SIK1 Alleviates the Pathologies of Psoriasis by Disrupting IL-17 Signaling. [Abstract]

2025 Feb 7:2025:3540219. PMID: 39959414

Solvant et solubilité

In Vitro:

DMSO : 25 mg/mL (47.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9023 mL

9.5113 mL

19.0226 mL

5 mM

0.3805 mL

1.9023 mL

3.8045 mL

10 mM

0.1902 mL

0.9511 mL

1.9023 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9023 mL	9.5113 mL	19.0226 mL	47.5565 mL
	5 mM	0.3805 mL	1.9023 mL	3.8045 mL	9.5113 mL
	10 mM	0.1902 mL	0.9511 mL	1.9023 mL	4.7557 mL
	15 mM	0.1268 mL	0.6341 mL	1.2682 mL	3.1704 mL
	20 mM	0.0951 mL	0.4756 mL	0.9511 mL	2.3778 mL
	25 mM	0.0761 mL	0.3805 mL	0.7609 mL	1.9023 mL
	30 mM	0.0634 mL	0.3170 mL	0.6341 mL	1.5852 mL
	40 mM	0.0476 mL	0.2378 mL	0.4756 mL	1.1889 mL

Keywords

YKL-06-062

2 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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YKL-06-062

Targeted Diversity Library

Bioactive Compound Library Max

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) YKL-06-062

Voir tous les produits spécifiques à Isoform Salt-inducible Kinase (SIK)

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

YKL-06-062

Targeted Diversity Library

Bioactive Compound Library Max

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) YKL-06-062

Voir tous les produits spécifiques à Isoform Salt-inducible Kinase (SIK)

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

YKL-06-062 Related Classifications

HY-129141 Related Classifications