YM-60828-d3
YM-60828-d3 is the deuterium labeled YM-60828 (HY-10280). YM-60828 is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 inhibits thrombus formation and platelet aggregation. YM-60828 can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders.
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- CAS No.: 1794812-00-2
- Formule: C27H28D3N5O5S
- Masse moléculaire:613.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1794812-00-2
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Unlabeled Cas 201933-41-7
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Masse moléculaire 613.57
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Formule C27H28D3N5O5S
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SMILES
N(CC1=CC2=C(C=C1)C=CC(C(=N)N)=C2)(S(CC(O)=O)(=O)=O)C3=CC=C(OC4CCN(C(C([2H])([2H])[2H])=N)CC4)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sato K, et al. Antithrombotic effects of YM-60828 in three thrombosis models in guinea pigs. Eur J Pharmacol. 1998;350(1):87-91. [Content Brief]
[2]. Hirayama F, et al. The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor. Bioorg Med Chem. 2002;10(5):1509-1523. [Content Brief]
[3]. Kawasaki T, et al. Effect of a synthetic factor Xa inhibitor, YM-60828, on blood vessel patency in combination with a thrombolytic agent and on blood loss from the operation site in a rat model of arterial thrombosis. Thromb Haemost. 1998;79(4):859-864. [Content Brief]
[4]. Kawasaki T, et al. Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis. Thromb Haemost. 1998;79(2):410-416. [Content Brief]
[5]. Taniuchi Y, et al. Biochemical and pharmacological characterization of YM-60828, a newly synthesized and orally active inhibitor of human factor Xa. Thromb Haemost. 1998;79(3):543-548. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YM-60828-d3 Related Classifications
HY-10280S Related Classifications
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