104947-69-5
Chemical Structure
Bengamide B
- CAS No.: 104947-69-5
- Formula:C32H58N2O8
- Molecular Weight:598.81
IUPAC Name: (3S,6S)-1-methyl-7-oxo-6-((2R,3R,4S,5R,E)-3,4,5-trihydroxy-2-methoxy-8-methylnon-6-enamido)azepan-3-yl tetradecanoate
InChIKey: PFRKTXMXGDERHT-UCDUEDMDSA-N
SMILES: CC(C)/C=C/[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC)C(N[C@H]1CC[C@H](OC(CCCCCCCCCCCCC)=O)CN(C)C1=O)=O
Biological Activity: Bengamide B is an alkaloid with anti-tumor and anti-inflammatory activities. Bengamide B reduces the phosphorylation level of IκBα, thereby blocking the activation of NF-κB. Bengamide B inhibits the proliferation of tumor cells. Bengamide B can be used in research related to inflammatory diseases and cancers[1][2].
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Bengamide B | Bengamide B is an alkaloid with anti-tumor and anti-inflammatory activities. Bengamide B reduces the phosphorylation level of IκBα, thereby blocking the activation of NF-κB. Bengamide B inhibits the proliferation of tumor cells. Bengamide B can be used in research related to inflammatory diseases and cancers. | |||||||||||||||||||||
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References
- [1]. Johnson TA, et al. Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg Med Chem. 2012;20(14):4348-4355. [Content Brief]
- [2]. Kinder FR Jr, et al. Synthesis and antitumor activity of ester-modified analogues of bengamide B. J Med Chem. 2001;44(22):3692-3699. [Content Brief]
