117-02-2
117-02-2
Chemical Structure
Rubiadin
- CAS No.: 117-02-2
- Formula:C15H10O4
- Molecular Weight:254.24
IUPAC Name: 1,3-dihydroxy-2-methylanthracene-9,10-dione
InChIKey: IRZTUXPRIUZXMP-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(C)C(O)=C13)=O
Biological Activity: Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections[1][2][3][4][5][6][7][8][9].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rubiadin | 99.56% | Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections. | ||||||||||||||||||||
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Rubiadin (Standard) | ≥98% | Rubiadin (Standard) is the analytical standard of Rubiadin (HY-N0444). This product is intended for research and analytical applications. Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections. | ||||||||||||||||||||
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Anthragallol | 99.55% | Anthragallol can insert base pairs of DNA. Anthragallol exhibits cytotoxicity by binding to DNA. | ||||||||||||||||||||
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Lucidin | 98.03% | Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells. | ||||||||||||||||||||
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Alizarin (Standard) | 96.56% | Alizarin (Standard) is the analytical standard of Alizarin. This product is intended for research and analytical applications. Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings. | ||||||||||||||||||||
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Lucidin-ω-Me ether | Lucidin-ω-Me ether (Compound 2) can be isolated from the roots of Knoxia valerianoides. Lucidin-ω-Me ether inhibits the advanced glycation end products (AGEs) formation in vitro(IC50: 62.79 μM). | |||||||||||||||||||||
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1-Hydroxy-2-methylanthraquinone | 1-Hydroxy-2-methylanthraquinone exhibits antimicrobial, antioxidant, pesticidal, and anti-inflammatory activities. | |||||||||||||||||||||
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Rubiadin-1-methyl ether | 98.57% | Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases. | ||||||||||||||||||||
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6-Hydroxyrubiadin | 99.79% | 6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases. | ||||||||||||||||||||
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Pachybasin | Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively. | |||||||||||||||||||||
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Xanthopurpurin | 97.03% | Xanthopurpurin is an orally active anthraquinone glycoside. Xanthopurpurin can be isolated from the rhizome of Rubia akane. Xanthopurpurin has antiviral effects against rotavirus and HIV. Xanthopurpurin has a strong inhibitory effect on collagen-induced platelet aggregation. Xanthopurpurin prevents peanut allergy. | ||||||||||||||||||||
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Anthragallol-2-methyl ether | Anthragallol-2-methyl ether (compound 4) can be isolated from the fruits of Morinda citrifolia. | |||||||||||||||||||||
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References
- [1]. Hui Huang, et al. Rubiadin Regulates Bone Metabolism in Ovariectomized Rat Model by Inhibition of osteoclast formation and differentiation. ChemistrySelect 2023, 8, e202300115 (1 of 11).
- [2]. Chitsaz R, et al. Rubiadin exerts an acute and chronic anti-inflammatory effect in rodents. Braz J Biol. 2021;83:e243775. Published 2021 Dec 13. [Content Brief]
- [3]. Rao GM, et al. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006;103(3):484-490. [Content Brief]
- [4]. Zhang Y, et al. Rubiadin Alleviates Alzheimer's Disease Pathology via NF-κB Pathway Regulation. J Integr Neurosci. 2025;24(10):33497. [Content Brief]
- [5]. Rumie Vittar NB, et al. Photochemotherapy using natural anthraquinones: Rubiadin and Soranjidiol sensitize human cancer cell to die by apoptosis. Photodiagnosis Photodyn Ther. 2014;11(2):182-192. [Content Brief]
- [6]. Xie X, et al. Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway. Int J Mol Sci. 2025;26(3):1385. Published 2025 Feb 6. [Content Brief]
- [7]. Peng Z, et al. Effects of Rubiadin isolated from Prismatomeris connata on anti-hepatitis B virus activity in vitro. Phytother Res. 2017;31(12):1962-1970. [Content Brief]
- [8]. Watroly MN, et al. Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development. Drug Des Devel Ther. 2021;15:4527-4549. Published 2021 Nov 3. [Content Brief]
- [9]. Hieu LT, et al. The Theoretical and Experimental Insights into the Radical Scavenging Activity of Rubiadin. J Phys Chem B. 2023;127(51):11045-11053. [Content Brief]
